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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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HLA-ABC Antibody Bra-23/9 reacts with a monomorphic determinant of human major histocompatibility (MHC) class I antigens (HLA-A, B and C). Immunoprecipitation of lactoperoxidase radioiodinated cell surface proteins and surface sialoglycoproteins radiolabeled by sodium metaperiodate/tritiated sodium borohydride technique confirmed the structure gp44,p12 (consisting of a 44kDa glycopeptide linked with a non-glycosylated 12kDa peptide) typical for MHC class I antigen(s) as a structure recognized by Bra23/9. Human MHC class I antigens are expressed constitutively on all nucleated cells lymphocytes such as lymphocytes, thymocytes, granulocytes, and bone marrow cells and are absent on erythrocytes. MHC class I antigens play a role in class I MHC-associated antigen presentation, inhibition of NK cell cytotoxicity, tumor surveillance, and tissue allotransplantation.
For additional information on HLA class I biology and complementary antibody validation, visit our HLA-ABC Antibody MHC-I/8147R / MHC Class I Antibody page.
Optimal dilution of the HLA-ABC Antibody Bra-23/9 should be determined by the researcher.
Human REH cells (a pre-B leukaemia cell line) was used as the immunogen for the HLA-ABC Antibody Bra-23/9.
Aliquot the HLA-ABC Antibody Bra-23/9 and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
HLA-ABC antibody, MHC Class I antibody, MHC I antibody, HLA Class I antibody, HLA-A antibody, HLA-B antibody, HLA-C antibody
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