- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
HLA-A Antibody (R31867)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
R31867 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 449 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Antigen affinity purified |
| Host | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Antigen affinity |
| Buffer | Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide |
| UniProt | P01892 |
| Applications | Western Blot : 0.1-0.5ug/ml Immunohistochemistry (FFPE) : 0.5-1ug/ml |
| Limitations | This HLA-A antibody is available for research use only. |
|
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HLA-A Antibody recognizes HLA-A, a classical major histocompatibility complex (MHC) class I molecule that plays a central role in adaptive immunity by presenting endogenous peptide antigens to CD8-positive cytotoxic T lymphocytes. HLA-A is expressed on the surface of nearly all nucleated cells and is essential for immune surveillance against viral infections, intracellular pathogens, and malignant transformation. As one of the most extensively studied human leukocyte antigens, HLA-A Antibody is widely used to investigate antigen presentation, immune recognition, transplantation biology, and tumor immunology.
HLA-A consists of a polymorphic alpha heavy chain that associates non-covalently with beta-2 microglobulin to form a functional peptide-presenting complex. Intracellular proteins are processed into short peptides that bind within the HLA-A peptide-binding groove before being transported to the cell surface for recognition by CD8-positive T cells. This antigen presentation pathway enables the immune system to distinguish healthy cells from those infected by viruses or altered through oncogenic transformation, thereby initiating targeted cytotoxic immune responses.
Altered HLA-A expression has significant clinical implications in organ and hematopoietic stem cell transplantation, autoimmune disease, infectious disease, and cancer. Many tumors reduce HLA-A expression to evade immune detection, whereas increased expression is frequently observed following interferon stimulation and during inflammatory responses. HLA-A typing remains a cornerstone of donor-recipient matching for transplantation, while assessment of HLA-A expression has become increasingly important in studies of immune checkpoint blockade, cancer immunotherapy, and mechanisms of immune escape.
NSJ Bioreagents' HLA-A Antibody supports investigations into antigen presentation, MHC class I biology, transplantation immunology, tumor immune surveillance, antiviral immunity, and T cell-mediated immune responses. Reliable detection of HLA-A enables researchers to study one of the principal molecules responsible for presenting intracellular antigens to the adaptive immune system.
Optimal dilution of the HLA-A antibody should be determined by the researcher.
Amino acids EYWDGETRKVKAHSQTHRVDLGTLR of human HLA-A were used as the immunogen for the HLA-A antibody.
After reconstitution, the HLA-A antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
HLA-A antibody, Human Leukocyte Antigen A antibody, MHC Class I HLA-A antibody, Major Histocompatibility Complex Class I A antibody, HLA Class I A antibody, HLA-A Heavy Chain antibody
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