- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Histone H2A (mono methyl K118) Antibody / HIST1H2A Nucleosome Stability Antibody [clone 31H85] (FY13228)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
FY13228 | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA | 100 ul | 449 |
| Availability | 2-3 weeks |
| Species Reactivity | Human, Mouse, Rat |
| Format | Liquid |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG |
| Clone Name | 31H85 |
| Purity | Affinity chromatography |
| Buffer | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
| UniProt | P04908 |
| Applications | Western Blot : 1:500-1:2000 Immunohistochemistry : 1:50-1:200 Immunocytochemistry/Immunofluorescence : 1:50-1:200 |
| Limitations | This Histone H2A (mono methyl K118) antibody is available for research use only. |
|
Review this product on BioCompare and get a $20 Amazon gift card
|
Related Products
|
Histone H2A (HIST1H2A) monomethylation at lysine 118 represents a structural chromatin modification associated with nucleosome stability and regulation of chromatin architecture. Histone H2A (mono methyl K118) Antibody / HIST1H2A Nucleosome Stability Antibody (clone 31H85) is designed to detect Histone H2A monomethylated at lysine 118, providing a marker of chromatin structural integrity and nucleosome organization. Included within the Histone H2A antibodies collection, this antibody enables analysis of histone modification patterns and chromatin regulatory mechanisms involving H2A and its variants.
HIST1H2A antibody, also referred to as Histone H2A antibody and H2AK118me1 antibody in the literature, recognizes a modification located within the core region of the nucleosome rather than the flexible histone tail. This positioning distinguishes it from many histone modifications that regulate transcription through accessibility changes.
This recombinant rabbit monoclonal clone 31H85 antibody is uniquely positioned for studies of chromatin structure and nucleosome dynamics. H2A lysine 118 monomethylation is associated with maintenance of nucleosome stability and proper chromatin compaction.
At the molecular level, methylation at lysine 118 may influence interactions between histone proteins within the nucleosome core, affecting DNA wrapping and nucleosome positioning. This modification contributes to the physical properties of chromatin rather than directly regulating transcriptional activation or repression.
Unlike acetylation marks that promote open chromatin or phosphorylation marks linked to signaling, H2AK118me1 reflects structural chromatin states. It may act as a stabilizing modification that preserves nucleosome integrity across genomic regions.
This modification is important for maintaining genome organization and ensuring proper chromatin folding, particularly in regions requiring consistent structural stability.
At the cellular level, H2A lysine 118 monomethylation localizes to the nucleus and is distributed across chromatin regions involved in structural organization. Its presence reflects chromatin architecture rather than transcriptional status.
This antibody supports detection of Lys118-monomethylated Histone H2A, enabling investigation of nucleosome stability, chromatin structure, and epigenetic regulation of genome organization.
Optimal dilution of the Histone H2A (mono methyl K118) Antibody / HIST1H2A Nucleosome Stability Antibody should be determined by the researcher.
A synthesized peptide derived from human Histone H2A (mono methyl K118) was used as the immunogen for the Histone H2A (mono methyl K118) Antibody / HIST1H2A Nucleosome Stability Antibody.
Store the Histone H2A (mono methyl K118) antibody at -20oC.
Histone H2A Lys118 monomethylation antibody, H2AK118me1 nucleosome stability antibody, mono methyl histone H2A Lys118 antibody, H2A K118 methyl antibody
Your bulk quote request has been submitted successfully!
Please contact us if you have any questions.
Powered by Bioz
Citations(1)
