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- Tel: 858.663.9055
- Email: info@nsjbio.com
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Hypoxia-inducible factor 1 alpha is a transcription factor that mediates cellular and systemic homeostatic responses to reduced availability in mammals, including angiogenesis, erythropoiesis and glycolysis. This gene was mapped to 14q21-q24. HIF1a transactivate genes required for energy metabolism and tissue perfusion and is necessary for embryonic development and tumor explant growth. It is over expressed during carcinogenesis, myocardial infarction and wound healing. It is crucial for the cellular response to hypoxia and is frequently over expressed in human cancers, resulting in the activation of genes essential for cell survival. HIF1a regulates the survival and function in the inflammatory microenvironment directly. It is a transcription factor that plays a pivotal role in cellular adaptation to changes in oxygen availability.
The stated application concentrations are suggested starting points. Titration of the HIF1a antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Amino acids 8-21 (NDKKKISSERRKEK-human) were used as the immunogen for this HIF1a antibody.
After reconstitution, the HIF1a antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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