- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
HGF Antibody / MET Receptor Ligand Antibody (R30164)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
R30164 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 449 |
|
| Availability | 1-3 business days |
| Species Reactivity | Human, Mouse, Rat |
| Format | Antigen affinity purified |
| Host | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Antigen affinity |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose |
| Gene ID | 15234 |
| Applications | Western Blot : 0.5-1ug/ml |
| Limitations | This HGF Antibody / MET Receptor Ligand Antibody is available for research use only. |
|
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HGF Antibody / MET Receptor Ligand Antibody recognizes hepatocyte growth factor, a multifunctional secreted protein encoded by the HGF gene. HGF was originally characterized through its ability to stimulate hepatocyte proliferation and was subsequently shown to be identical to scatter factor, a protein identified independently through its effects on epithelial cell motility. HGF functions as a mitogen, motogen and morphogen and has important roles in tissue development, regeneration and cellular responses to injury.
HGF is synthesized as an inactive single-chain precursor and undergoes proteolytic processing to generate the biologically active two-chain form. Structurally, the protein contains an N-terminal domain, four kringle domains and a C-terminal serine protease homology domain, although HGF itself lacks protease activity. This multidomain organization enables interactions required for receptor binding and activation.
The receptor for HGF is the MET receptor tyrosine kinase. Binding of HGF to MET initiates signaling pathways that regulate proliferation, survival, migration and morphogenesis. HGF-MET signaling is particularly important in epithelial-mesenchymal interactions and contributes to processes such as embryonic development and tissue regeneration. Dysregulation of the HGF-MET axis has also been extensively investigated in cancer, where aberrant pathway activity can contribute to tumor growth, invasive behavior and metastatic progression.
This rabbit polyclonal antibody was generated against a recombinant fragment of human HGF and is antigen affinity purified. NSJ Bioreagents provides this HGF Antibody for research into growth factor expression, MET signaling, tissue regeneration and cancer biology. A MET Receptor Ligand Antibody can support studies examining the expression and biological regulation of HGF within this important growth factor signaling pathway.
Explore our Growth Factor Antibodies page for additional reagents targeting proteins involved in cell proliferation, differentiation, migration and growth factor signaling.
The stated application concentrations are suggested starting amounts. Titration of the HGF Antibody / MET Receptor Ligand Antibody may be required due to differences in protocols and secondary/substrate sensitivity.
An amino acid sequence from the N-terminus of mouse HGF (QKKRRNTLHEFKKSAKTTLTKEDPLLKIKTKK) was used as the immunogen for this HGF antibody.
After reconstitution, the HGF antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
HGF antibody, hepatocyte growth factor antibody, scatter factor antibody, SF antibody, hepatopoietin A antibody
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