- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
ErbB2 Antibody / HER2 Signaling Receptor Antibody [clone HRB2/718] (V2111)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V2111-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
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V2111-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
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V2111SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1, kappa |
| Clone Name | HRB2/718 |
| Purity | Protein G affinity chromatography |
| Buffer | 1X PBS, pH 7.4 |
| Gene ID | 2064 |
| Localization | Extracellular/Intracellular cell membrane |
| Applications | ELISA : order BSA/sodium azide-free format for coating Flow Cytometry : 1-2ug/million cells Immunofluorescence : 0.5-1ug/ml |
| Limitations | This ErbB2 Antibody / HER2 Signaling Receptor Antibody is available for research use only. |
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ErbB2 receptor tyrosine kinase 2 (ERBB2), also known as HER2, is a signaling receptor that plays a central role in regulating cellular growth, differentiation, and survival. ErbB2 Antibody / HER2 Signaling Receptor Antibody (clone HRB2/718) targets this protein, which is localized primarily at the cell membrane and participates in complex intracellular signaling networks. ErbB2 antibody, also referred to as HER2 antibody and ERBB2 antibody in the literature, detects a key component of receptor-mediated signaling pathways that influence both normal cellular function and disease progression. This antibody is part of a collection of Human Protein Microarray validated antibodies that have been screened for specificity across thousands of proteins.
Functionally, ErbB2 acts as a preferred dimerization partner within the epidermal growth factor receptor family, enabling activation of downstream signaling cascades such as PI3K/AKT, MAPK, and JAK/STAT pathways. These pathways regulate essential cellular processes including proliferation, apoptosis resistance, and migration. The ability of ErbB2 to amplify signaling through heterodimer formation contributes to its potent biological effects, particularly in rapidly dividing or transformed cells.
ErbB2 expression is widely studied in cancer biology, where overexpression or amplification of the ERBB2 gene is associated with aggressive tumor behavior and altered signaling dynamics. Detection of ErbB2 supports investigation of pathway activation and receptor signaling intensity in tumor cells, as well as evaluation of therapeutic strategies targeting receptor function. In addition to oncology, ErbB2 signaling contributes to normal developmental processes and tissue homeostasis.
In immunofluorescence and flow cytometry applications, ErbB2 is typically observed as a membrane-associated receptor with additional cytoplasmic signal reflecting receptor trafficking and turnover. These techniques enable analysis of receptor distribution, expression levels, and population heterogeneity in cell-based systems. The ability to monitor ErbB2 signaling components in different cellular contexts supports studies of pathway regulation and cellular responses to environmental cues.
Structurally, ErbB2 contains an extracellular domain responsible for receptor interactions, a transmembrane region anchoring it to the plasma membrane, and an intracellular tyrosine kinase domain that mediates signal transduction. Upon activation, phosphorylation of key residues initiates downstream signaling events that regulate gene expression and cellular behavior.
Protein microarray validation confirms specific detection of ErbB2 by this antibody, supporting reliable identification of the target in signaling-focused studies. Combined with IF and FACS applications, this antibody enables detailed analysis of receptor-mediated pathways. For broad detection of HER2 (ErbB2) as a receptor tyrosine kinase, see our HER2 antibody.
The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the antibody to be titered up or down for optimal performance.
1. This ErbB2 Antibody / HER2 Signaling Receptor Antibody binds to the extracellular/cell surface region of the protein.
Recombinant human HER2 protein was used as the immunogen for this HER2 / ErbB2 antibody. Its epitope is localized in the extracellular domain.
Store the HER2 / ErbB2 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
ErbB2 antibody, HER2 antibody, ERBB2 antibody, ErbB2 signaling antibody, HER2 pathway antibody
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