- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
HER-4 Antibody Clone HFR-1 / ERBB4 [clone HFR-1] (V7741)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V7741-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
|
|
V7741-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
|
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V7741SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG2b, kappa |
| Clone Name | HFR-1 |
| Purity | Protein G affinity chromatography |
| UniProt | Q15303 |
| Localization | Cytoplasmic, plasma membrane, nuclear |
| Applications | Flow Cytometry : 1-2ug/million cells in 0.1ml Immunofluorescence : 1-2ug/ml |
| Limitations | This HER-4 antibody is available for research use only. |
|
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HER-4 Antibody clone HFR-1 recognizes Erb-B2 receptor tyrosine kinase 4, also known as ERBB4, a member of the epidermal growth factor receptor family of receptor tyrosine kinases. HER-4 antibody, frequently referred to as ERBB4 antibody and ErbB4 antibody in the literature, detects a transmembrane receptor involved in growth factor signaling, cellular differentiation, and survival pathways. Clone HFR-1 is produced as a mouse monoclonal antibody and has been referenced in numerous peer-reviewed publications investigating HER4 biology and ERBB signaling mechanisms.
HER4 belongs to the ERBB receptor family, which includes EGFR, HER2, and HER3. Upon ligand binding, including neuregulins and other EGF-like growth factors, HER4 undergoes receptor dimerization and autophosphorylation, activating downstream PI3K-AKT, MAPK, and JAK-STAT pathways. These signaling cascades regulate proliferation, differentiation, and apoptosis in epithelial, neural, and cardiac tissues. Unlike certain other ERBB family members, HER4 can undergo regulated intramembrane proteolysis, releasing an intracellular domain that translocates to the nucleus and influences gene transcription.
The ERBB4 gene is located on chromosome 2q34 and produces multiple isoforms through alternative splicing. These isoforms differ in their cytoplasmic tail composition and downstream signaling capacity, contributing to context-dependent biological effects. HER4 expression has been documented in breast epithelium, neural tissue, and cardiac muscle, where it contributes to developmental regulation and tissue homeostasis.
Dysregulation of HER4 signaling has been implicated in breast cancer, ovarian carcinoma, and other malignancies. Depending on isoform expression and cellular context, HER4 may demonstrate differentiation-associated or tumor-modulating roles. Because of this complexity, consistent detection using a well-characterized clone such as HFR-1 supports reproducibility across independent studies.
HER-4 Antibody Clone HFR-1 is suitable for research applications focused on ERBB4 signaling, receptor tyrosine kinase biology, and cancer-related growth factor pathway analysis. Its established use in published studies makes clone HFR-1 a recognized tool in HER4 research.
Optimal dilution of the HER-4 antibody should be determined by the researcher.
A recombinant human partial protein (amino acids 1116-1269) was used as the immunogen for the HER-4 antibody.
Store the HER-4 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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