- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Hepatocyte nuclear factor 1 beta Antibody / HNF1B [clone HNF1B/9518] (V6007)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V6007-100UG | 0.2 mg/ml in 1X PBS with 0.05% BSA, 0.05% sodium azide | 100 ug | 559 | |
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V6007-20UG | 0.2 mg/ml in 1X PBS with 0.05% BSA, 0.05% sodium azide | 20 ug | 259 | |
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V6007SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG2a, kappa |
| Clone Name | HNF1B/9518 |
| UniProt | P35680 |
| Localization | Nucleus |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This Hepatocyte nuclear factor 1 beta/HNF1B antibody is available for research use only. |
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Hepatocyte nuclear factor 1 beta antibody, also known as HNF1B antibody, recognizes a homeodomain-containing transcription factor encoded by the human HNF1B gene located on chromosome 17q12. HNF1B is a member of the HNF1 family of transcription regulators and is predominantly localized to the nucleus, where it controls gene expression programs essential for epithelial differentiation and organ development. Hepatocyte nuclear factor 1 beta antibody is widely used in research examining renal, pancreatic, and hepatobiliary biology as well as epithelial lineage specification.
HNF1B contains a dimerization domain, a POU-specific DNA-binding domain, and a transactivation domain that enables transcriptional activation of target genes. It functions as a homodimer or heterodimer with HNF1 alpha and binds specific promoter regions to regulate genes involved in glucose metabolism, ion transport, and epithelial polarity. During embryogenesis, HNF1B plays a critical role in nephrogenesis, pancreatic duct development, and biliary tract formation. Hepatocyte nuclear factor 1 beta antibody supports investigation of transcriptional regulation and developmental gene networks.
HNF1B expression is strongly detected in renal tubular epithelial cells, bile duct epithelium, pancreatic ductal cells, and select reproductive tract epithelia. Alterations in HNF1B have been associated with renal cysts and diabetes syndrome and congenital anomalies of the kidney and urinary tract. In tumor research, nuclear HNF1B expression has been studied in ovarian clear cell carcinoma and certain renal neoplasms, where it serves as a lineage-associated marker in research settings. Hepatocyte nuclear factor 1 beta antibody enables evaluation of nuclear localization and epithelial differentiation status in normal and neoplastic tissues.
Beyond developmental roles, HNF1B regulates genes involved in metabolic homeostasis and epithelial transport function. Dysregulation of HNF1B activity may contribute to metabolic abnormalities and structural defects in affected organs. Clone HNF1B/9518 is designed to recognize HNF1B for research applications. This antibody targets Hepatocyte nuclear factor 1 beta in research settings and supports studies of transcriptional control, epithelial biology, and organ-specific gene regulation.
Optimal dilution of the Hepatocyte nuclear factor 1 beta/HNF1B antibody should be determined by the researcher.
A recombinant fragment (around amino acids 1-200) of human HNF1B protein (exact sequence is proprietary) was used as the immunogen for the Hepatocyte nuclear factor 1 beta/HNF1B antibody.
Hepatocyte nuclear factor 1 beta/HNF1B antibody with sodium azide - store at 2 to 8oC; antibody without sodium azide - store at -20 to -80oC.
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