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Home >> Antibodies >> HDAC4 Antibody

HDAC4 Antibody (F43191)

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  Catalog No Formulation Size Price (USD)  
Image F43191-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 399
Image
F43191-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 185
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HDAC4 antibody western blot analysis in NCI-H292 lysate. Expected molecular weight: ~140 kDa (full length), ~95 kDa (truncated).
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HDAC4 antibody western blot analysis in NCI-H292 lysate. Expected molecular weight: ~140 kDa (full length), ~95 kDa (truncated).
HDAC4 antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human testis tissue.
Fluorescent confocal image of HeLa cell stained with HDAC4 antibody at 1:25. HDAC4 immunoreactivity is localized to the nucleus.
Availability 1-3 business days
Species Reactivity Human
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Antigen affinity
UniProt P56524
Localization Nucleus
Applications Western blot : 1:1000
IHC (Paraffin) : 1:10-1:50
Immunofluorescence : 1:10-1:50
Limitations This HDAC4 antibody is available for research use only.
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Description

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.

Application Notes

Titration of the HDAC4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

A portion of amino acids 1049-1077 from the human protein was used as the immunogen for this HDAC4 antibody.

Storage

Aliquot the HDAC4 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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