- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
HDAC10 Antibody / Polyamine Deacetylase HDAC10 Antibody (RQ4431)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
RQ4431 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 449 |
|
| Availability | 1-3 business days |
| Species Reactivity | Human, Mouse, Rat |
| Format | Antigen affinity purified |
| Host | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Antigen affinity purified |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose |
| UniProt | Q969S8 |
| Applications | Western Blot : 0.5-1ug/ml Direct ELISA : 0.1-0.5ug/ml (recombinant human protein) (BSA-free format available) |
| Limitations | This HDAC10 Antibody / Polyamine Deacetylase HDAC10 Antibody is available for research use only. |
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HDAC10 Antibody / Polyamine Deacetylase HDAC10 Antibody recognizes histone deacetylase 10, an enzyme encoded by the HDAC10 gene. HDAC10 belongs to the class IIb histone deacetylase family and contains an N-terminal catalytic domain followed by a second, incomplete catalytic-like domain. Although historically classified according to its relationship with histone deacetylases, HDAC10 has emerged as a polyamine deacetylase with strong activity toward acetylated polyamines. This biochemical function distinguishes HDAC10 from many other members of the HDAC family and connects the enzyme with regulation of intracellular polyamine metabolism.
HDAC10 functions as a zinc-dependent deacetylase and is particularly associated with removal of acetyl groups from N8-acetylspermidine and related polyamine substrates. Polyamines such as spermidine and spermine participate in numerous cellular processes, including proliferation, nucleic acid interactions, translation and responses to cellular stress. Deacetylation can promote recycling of acetylated polyamines and influence their intracellular availability. An HDAC10 Antibody can therefore support research examining the relationship between deacetylase activity, polyamine homeostasis and cellular metabolism.
HDAC10 has also been investigated in autophagy, lysosomal biology, DNA damage responses and regulation of cell survival. Its activity can influence cellular adaptation to stress and has attracted particular interest in cancer biology, where altered HDAC10 expression or function may contribute to tumor cell survival and therapeutic resistance. A Polyamine Deacetylase HDAC10 Antibody provides a useful reagent for investigating these functions while distinguishing HDAC10 from HDAC family members whose principal biological activities are more closely associated with chromatin regulation.
Interest in HDAC10 also extends to the development of selective deacetylase inhibitors and efforts to understand how polyamine metabolism interacts with cancer, neurological biology and cellular homeostasis. Alternative splicing produces multiple HDAC10 transcript variants, adding further complexity to the regulation of this enzyme. NSJ Bioreagents provides this polyclonal reagent for researchers investigating HDAC10 biology and deacetylase function. An HDAC10 Antibody provides a useful tool for studying polyamine deacetylase HDAC10 and its roles in polyamine metabolism, cellular stress responses and regulatory pathways.
This HDAC10 Antibody is part of our Epigenetics Antibodies collection.
Optimal dilution of the HDAC10 Antibody / Polyamine Deacetylase HDAC10 Antibody should be determined by the researcher.
A human partial recombinant protein corresponding to amino acids T3-Q290 was used as the immunogen for the HDAC10 antibody.
After reconstitution, the HDAC10 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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