- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
HDAC1 Antibody PCRP-HDAC1-1B7 / Class I HDAC Antibody [clone PCRP-HDAC1-1B7] (V9651)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V9651-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
|
V9651-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
|
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V9651SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG |
| Clone Name | PCRP-HDAC1-1B7 |
| Purity | Protein A/G affinity |
| UniProt | Q13547 |
| Applications | ELISA (order BSA-free Format For Coating) : Flow Cytometry : 1-2ug/million cells Immunofluorescence : 1-2ug/ml |
| Limitations | This HDAC1 Antibody PCRP-HDAC1-1B7 / Class I HDAC Antibody is available for research use only. |
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HDAC1 Antibody PCRP-HDAC1-1B7 / Class I HDAC Antibody recognizes histone deacetylase 1, a nuclear enzyme encoded by the HDAC1 gene. HDAC1 belongs to the Class I family of histone deacetylases and removes acetyl groups from lysine residues on histones and other protein substrates. Histone deacetylation can promote a more compact chromatin environment and influence access of transcriptional machinery to DNA, making HDAC1 an important regulator of epigenetic gene expression.
HDAC1 functions primarily as a component of multiprotein transcriptional regulatory complexes rather than acting independently. Together with the closely related HDAC2 protein, HDAC1 is incorporated into complexes including Sin3, NuRD and CoREST. These assemblies recruit deacetylase activity to specific chromatin regions and participate in transcriptional repression, chromatin remodeling and regulation of cellular differentiation. The composition and recruitment of individual complexes provide important mechanisms for directing Class I HDAC activity within the nucleus.
Through its effects on chromatin and transcription, HDAC1 contributes to processes including cell-cycle progression, DNA damage responses, differentiation and development. Dysregulated HDAC activity has also been investigated extensively in cancer biology, where altered epigenetic regulation can contribute to abnormal gene-expression programs. HDAC1 and related histone deacetylases are consequently important research targets in studies of chromatin biology, transcriptional regulation and therapeutic epigenetics.
Clone PCRP-HDAC1-1B7 is a mouse monoclonal antibody generated against recombinant full-length human HDAC1 protein. The clone has been evaluated using a human protein microarray as well as cell-based assays, providing complementary approaches for examining antibody recognition. NSJ Bioreagents provides this HDAC1 Antibody for research into chromatin regulation, histone deacetylation and epigenetic control of gene expression. A Class I HDAC Antibody can support studies examining HDAC-associated transcriptional and chromatin regulatory mechanisms.
Explore our Epigenetics Antibodies page for additional reagents targeting proteins involved in chromatin remodeling, histone modification and epigenetic regulation of gene expression.
Optimal dilution of the HDAC1 Antibody PCRP-HDAC1-1B7 / Class I HDAC Antibody should be determined by the researcher.
Recombinant full-length human protein was used as the immunogen for the HDAC1 antibody.
Aliquot the HDAC1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
HDAC1 antibody, Histone deacetylase 1 antibody, HD1 antibody, Class I HDAC antibody, Histone deacetylase 1A antibody
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