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Home >> Antibodies >> HDAC1 Antibody

HDAC1 Antibody [clone 1061CT1.3.1] (F52270)

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  Catalog No Formulation Size Price (USD)  
Image F52270-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 399
Image
F52270-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 185
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HDAC1 antibody western blot analysis in (1) HeLa, (2) WiDr, and (3) Jurkat lysate. Predicted molecular weight 55~60 kDa
HDAC1 antibody western blot analysis in (1) HeLa, (2) WiDr, and (3) Jurkat lysate. Predicted molecular weight 55~60 kDa
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgM, k
Clone Name 1061CT1.3.1
Purity Purified
UniProt Q13547
Applications Western blot : 1:1000
Limitations This HDAC1 antibody is available for research use only.
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Description

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Component a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development.

Application Notes

Titration of the HDAC1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

Purified His-tagged protein was used to produced this monoclonal HDAC1 antibody.

Storage

Aliquot the HDAC1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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