- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
HAUS7 Antibody / UCHL5IP [clone 30H47] (FY12620)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
FY12620 | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA | 100 ul | 439 |
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HAUS7 antibody detects HAUS augmin-like complex subunit 7, a protein encoded by the HAUS7 gene that contributes to mitotic spindle organization. HAUS7 is part of the augmin complex, an eight-subunit assembly that recruits gamma tubulin ring complexes to existing microtubules, amplifying spindle microtubule formation during mitosis. This process ensures accurate chromosome alignment and segregation, supporting genomic stability.
HAUS7 antibody is widely used in cell biology and cancer research. The augmin complex promotes branching microtubule nucleation, a mechanism essential for robust spindle assembly in dividing cells. By detecting HAUS7, researchers can study how spindle architecture is generated and maintained. Disruption of augmin components leads to spindle defects, chromosome missegregation, and aneuploidy, processes often linked to tumorigenesis.
Western blot assays detect HAUS7 protein bands in dividing cell extracts. Immunohistochemistry highlights HAUS7 expression in proliferative tissues, while immunofluorescence maps localization at mitotic spindles. These approaches allow detailed analysis of augmin function in cell division.
HAUS7 and other augmin subunits play roles in neural stem cell division, embryonic development, and tissue regeneration. Their contribution to faithful chromosome segregation highlights their importance for preventing genomic instability and disease. By applying HAUS7 antibody, scientists can investigate mechanisms linking spindle regulation to cancer and developmental disorders.
HAUS7 antibody from NSJ Bioreagents provides dependable specificity for studying microtubule nucleation and spindle organization. Its strong performance across methods ensures accurate detection in diverse research contexts.
Optimal dilution of the HAUS7 antibody should be determined by the researcher.
A synthesized peptide derived from human UCHL5IP was used as the immunogen for the HAUS7 antibody.
Store the HAUS7 antibody at -20oC.
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