- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
TFII-I Antibody / GTF2I Transcription Factor Antibody [clone PCRP-GTF2I-1A7] (V5205)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V5205-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
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V5205-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V5205SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG2b |
| Clone Name | PCRP-GTF2I-1A7 |
| Purity | Protein A/G affinity |
| UniProt | P78347 |
| Localization | Nucleus |
| Applications | Flow Cytometry : 1-2ug/million cells |
| Limitations | This TFII-I Antibody / GTF2I Transcription Factor Antibody is available for research use only. |
|
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TFII-I Antibody / GTF2I Transcription Factor Antibody recognizes GTF2I, a multifunctional DNA-binding transcriptional regulator commonly known as TFII-I. GTF2I participates in RNA polymerase II-dependent gene regulation and can interact with both promoter elements and signal-responsive transcriptional machinery. The protein therefore provides a molecular connection between transcriptional control and cellular signaling pathways that influence gene expression.
GTF2I can bind promoter elements including pyrimidine-rich initiator sequences and E-box motifs and functions as a transcriptional coregulator in multiple contexts. It participates in formation of regulatory complexes at the C-FOS promoter and can cooperate with serum response factor-associated proteins to influence signal-responsive transcription. GTF2I has also been described as BAP135 because of its association with Bruton's tyrosine kinase, further reflecting its relationship with signaling-dependent transcriptional regulation.
Beyond these activities, GTF2I contributes to transcriptional complexes involved in cellular differentiation and gene regulation. It participates in formation of functional ARID3A DNA-binding complexes and has been implicated in activation of immunoglobulin heavy-chain transcription following B-lymphocyte activation. GTF2I is consequently studied in research involving transcription factor biology, promoter regulation, signal-responsive gene expression and developmental mechanisms.
Clone PCRP-GTF2I-1A7 is a mouse monoclonal antibody generated against recombinant human GTF2I protein and purified by Protein A/G affinity chromatography. The antibody has been evaluated on a HuProt protein microarray containing more than 19,000 full-length human proteins. NSJ Bioreagents provides this TFII-I Antibody for research into transcriptional regulation and GTF2I biology. A GTF2I Transcription Factor Antibody can support investigation of TFII-I and its role in connecting promoter activity with cellular signaling.
For a GTF2I reagent validated across WB, IHC, IF and FACS, visit our GTF2I Antibody / General Transcription Factor II-I Antibody page.
Optimal dilution of the TFII-I Antibody / GTF2I Transcription Factor Antibody should be determined by the researcher.
Recombinant human protein was used as the immunogen for the GTF2I / TFII-I antibody.
Aliquot the GTF2I / TFII-I antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
TFII-I antibody, GTF2I antibody, general transcription factor II-I antibody, GTFII-I antibody, BAP135 antibody, WBSCR6 antibody
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