- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
GSTP1 Antibody / Glutathione S-transferase pi 1 [clone GSTP1/12956R] (V5908)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V5908-100UG | 0.2 mg/ml in 1X PBS with 0.05% BSA, 0.05% sodium azide | 100 ug | 559 | |
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V5908-20UG | 0.2 mg/ml in 1X PBS with 0.05% BSA, 0.05% sodium azide | 20 ug | 259 | |
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V5908SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | GSTP1/12956R |
| Purity | Protein A affinity |
| UniProt | P09211 |
| Localization | Cytoplasm, Mitochondrion, Nucleus |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml Western Blot : 2-4ug/ml Knockdown : |
| Limitations | This GSTP1/Glutathione S-transferase pi 1 antibody is available for research use only. |
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GSTP1 antibody targets Glutathione S-transferase pi 1, a cytosolic phase II detoxification enzyme encoded by the GSTP1 gene. Glutathione S-transferase pi 1 belongs to the pi class of glutathione S-transferases and catalyzes the conjugation of reduced glutathione to a wide range of electrophilic compounds, facilitating their detoxification and elimination. GSTP1 is also commonly referred to as GST pi, GSTP, or GST-pi, and a GSTP1 antibody is widely used to study cellular defense mechanisms against oxidative stress and xenobiotic injury.
Glutathione S-transferase pi 1 is broadly expressed in epithelial tissues and plays a central role in protecting cells from reactive oxygen species, lipid peroxidation products, and environmental toxins. In normal physiology, GSTP1 contributes to redox balance and cellular homeostasis by neutralizing potentially harmful metabolites. Beyond its enzymatic detoxification activity, GSTP1 also participates in non-catalytic signaling functions, including modulation of stress-activated kinase pathways such as JNK signaling. A Glutathione S-transferase pi 1 antibody therefore supports investigations into both metabolic detoxification and stress response regulation.
GSTP1 has significant relevance in cancer biology and toxicology research. Overexpression of Glutathione S-transferase pi 1 is frequently observed in a wide range of solid tumors, including cancers of the lung, breast, colon, prostate, and ovary. Elevated GSTP1 levels are associated with enhanced cellular resistance to chemotherapeutic agents and environmental carcinogens, making GSTP1 a key marker of drug resistance and tumor adaptation. Use of a GSTP1 antibody enables analysis of detoxification capacity, chemoresistance mechanisms, and oxidative stress responses in tumor tissues.
In prostate biology, GSTP1 is particularly notable due to its characteristic epigenetic silencing in prostate adenocarcinoma. Hypermethylation of the GSTP1 promoter leads to loss of Glutathione S-transferase pi 1 expression in malignant prostate epithelial cells, while surrounding benign tissue often retains expression. This unique expression pattern has made GSTP1 a well-established molecular marker in prostate cancer research. A Glutathione S-transferase pi antibody is therefore commonly applied in studies of prostate tumorigenesis and epigenetic regulation.
Structurally, Glutathione S-transferase pi 1 functions as a homodimer and shares conserved domains with other glutathione S-transferase family members. Its activity and expression are regulated by oxidative stress, xenobiotic exposure, and transcriptional control mechanisms linked to cellular defense pathways. Because GSTP1 expression reflects both environmental exposure and cellular stress status, GSTP1 antibody reagents are valuable tools for toxicology, cancer metabolism, and redox biology research.
Clone GSTP1/12956R is designed to recognize Glutathione S-transferase pi 1 and supports detection of GSTP1 expression in research applications. NSJ Bioreagents offers this GSTP1 antibody to support studies of detoxification enzymes, oxidative stress signaling, cancer biology, and drug response mechanisms.
1. Optimal dilution of the GSTP1/Glutathione S-transferase pi 1 antibody should be determined by the researcher.
2. This GSTP1/Glutathione S-transferase pi 1 antibody is recombinantly produced by expression in CHO cells.
A recombinant fragment (around amino acids 19-206) of human full-length GSTP1 protein (exact sequence is proprietary) was used as the immunogen for the GSTP1/Glutathione S-transferase pi 1 antibody.
GSTP1/Glutathione S-transferase pi 1 antibody with sodium azide - store at 2 to 8oC; antibody without sodium azide - store at -20 to -80oC.
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