- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
GSTM2 Antibody / Glutathione S-transferase Mu 2 (FY12861)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
FY12861 | Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml | 100 ug | 439 |
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GSTM2 antibody detects Glutathione S-transferase Mu 2, a detoxification enzyme that catalyzes the conjugation of glutathione to electrophilic compounds, protecting cells from oxidative damage and xenobiotic stress. Encoded by the GSTM2 gene on chromosome 1p13.3, this enzyme belongs to the mu class of cytosolic glutathione S-transferases (GSTs) and plays a critical role in the metabolism of carcinogens, environmental toxins, and therapeutic drugs. GSTM2 is particularly abundant in liver, kidney, and lung tissues, where it contributes to phase II detoxification.
Structurally, GSTM2 forms homodimers, each monomer containing an N-terminal glutathione-binding site (G-site) and a C-terminal hydrophobic substrate-binding site (H-site). This configuration enables GSTM2 to catalyze the conjugation of reduced glutathione (GSH) to electrophilic substrates, rendering them more water-soluble for excretion. GSTM2 also exhibits peroxidase activity, neutralizing reactive oxygen species and maintaining cellular redox balance.
The GSTM2 antibody is widely used in toxicology, pharmacology, and metabolic research to study oxidative stress responses, detoxification pathways, and enzyme induction mechanisms. Western blot analysis identifies a 26 kilodalton band corresponding to GSTM2, while immunohistochemistry reveals strong cytoplasmic staining in hepatocytes and renal tubular cells. This antibody supports investigations into tissue-specific detoxification and metabolic adaptation to stress and xenobiotics.
Genetic polymorphisms in GSTM2 and related GST genes influence susceptibility to environmental toxins, carcinogens, and drug-induced injury. Reduced expression or functional loss of GSTM2 increases oxidative damage and contributes to disorders such as asthma, cancer, and neurodegenerative disease. Conversely, elevated expression is associated with chemoresistance and altered drug metabolism in tumor cells. The GSTM2 antibody provides a reliable tool for quantifying enzyme expression and understanding its contribution to cellular defense systems. NSJ Bioreagents validates this antibody for western blotting, immunohistochemistry, and immunofluorescence, ensuring dependable performance for detoxification and redox biology research.
Optimal dilution of the GSTM2 antibody should be determined by the researcher.
A synthetic peptide corresponding to a sequence in the middle region of mouse GSTM2 was used as the immunogen for the GSTM2 antibody.
After reconstitution, the GSTM2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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