- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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GSTM2 Antibody / Glutathione S-Transferase Mu 2 Antibody recognizes GSTM2, a cytosolic enzyme belonging to the mu class of glutathione S-transferases. GSTM2 participates in cellular detoxification by catalyzing the conjugation of reduced glutathione to electrophilic compounds. Through this activity, the enzyme helps protect cells from reactive products generated by oxidative stress as well as environmental toxins, carcinogens and other xenobiotic compounds.
GSTM2 is one of several closely related mu class GST enzymes encoded by a gene cluster on chromosome 1. Members of this family contribute to glutathione-dependent metabolism and cellular defense against potentially damaging chemical compounds. GSTM2 is particularly associated with muscle and has historically been referred to as GST muscle. The protein is consequently relevant to research involving muscle biology in addition to oxidative stress, xenobiotic metabolism and cellular detoxification.
Mu class glutathione S-transferases are highly polymorphic, and genetic variation within this family can influence the metabolism of environmental chemicals and therapeutic compounds. GST enzymes have therefore been widely investigated in toxicology, pharmacology and cancer research. Changes in GST activity or expression can alter cellular exposure to electrophilic compounds and products of oxidative stress, potentially affecting susceptibility to cellular damage and disease.
Clone CPTC-GSTMu2-2 is a mouse monoclonal antibody generated against full-length recombinant human GSTM2 and purified by Protein G affinity chromatography. NSJ Bioreagents provides this GSTM2 Antibody for research into GSTM2 biology, glutathione-dependent detoxification and cellular defense mechanisms. A Glutathione S-Transferase Mu 2 Antibody can support investigation of this mu class enzyme and its roles in xenobiotic metabolism, oxidative stress and muscle-associated biology.
Explore our Cancer Marker Antibodies page for additional reagents targeting proteins involved in tumor biology, cellular stress responses and cancer-related metabolic pathways.
Optimal dilution of the GSTM2 Antibody / Glutathione S-Transferase Mu 2 Antibody should be determined by the researcher.
1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
Full length recombinant human protein was used as the immunogen for this GSTM2 antibody.
Store the GSTM2 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
GSTM2 antibody, Glutathione S-Transferase Mu 2 antibody, GST Mu 2 antibody, GST muscle antibody
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