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Home >> Antibodies >> GSTM2 Antibody

GSTM2 Antibody [clone CPTC-GSTMu2-2] (V7416)

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  Catalog No Formulation Size Price (USD)  
Image V7416-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 100 ug 519
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V7416-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 20 ug 229
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V7416SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
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V7416IHC-7ML Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only* 7 ml 519
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Immunofluorescent staining of fixed and permeabilized human HeLa cells with GSTM2 antibody (green) and Reddot nuclear stain (red).
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Immunofluorescent staining of fixed and permeabilized human HeLa cells with GSTM2 antibody (green) and Reddot nuclear stain (red).
IHC staining of FFPE human placental tissue with GSTM2 antibody (clone CPTC-GSTMu2-2). HIER: boil tissue sections in pH6, 10mM citrate buffer, for 10-20 min and allow to cool before testing.
Western blot testing of human liver lysate with GSTM2 antibody (clone CPTC-GSTMu2-2).
Flow cytometry testing of PFA-fixed human HeLa cells with GSTM2 antibody (clone CPTC-GSTMu2-2); Red=isotype control, Blue= GSTM2 antibody.
SDS-PAGE analysis of purified, BSA-free GSTM2 antibody (clone CPTC-GSTMu2-2) as confirmation of integrity and purity.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG1, kappa
Clone Name CPTC-GSTMu2-2
Purity Protein G affinity chromatography
UniProt P28161
Localization Cytoplasmic
Applications Flow cytometry : 1-2ug/million cells
Immunofluorescence : 1-2ug/ml
Immunohistochemistry (FFPE) : 0.5-1ug/ml for 30 min at RT
Limitations This GSTM2 antibody is available for research use only.
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Description

Members of the glutathione S-transferase (GST) family of proteins function in the detoxification of xenobiotics to protect cells against toxicant-induced damage. There are eight families of GST proteins, each of which are composed of proteins that have a variety of functions throughout the cell. The GSTM proteins (GSTM1-GSTM5 in human and GSTM1-GSTM7 in mouse) are members of the mu class of enzymes that conjugate with glutathione and function in the detoxification of carcinogens, environmental toxins and products of oxidative stress. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene. GSTM2 is specific for muscle hence the alternate name GST muscle antibody.

Application Notes

Optimal dilution of the GSTM2 antibody should be determined by the researcher.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Immunogen

Full length recombinant human protein was used as the immunogen for this GSTM2 antibody.

Storage

Store the GSTM2 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

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