- Tel: 858.663.9055
- Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found.
The stated application concentrations are suggested starting points. Titration of the GSR antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 380-408 from the human protein was used as the immunogen for the GSR antibody.
Aliquot the GSR antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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