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Home >> Antibodies >> GRB10 Antibody

GRB10 Antibody [clone 5H7] (RQ6357)

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  Catalog No Formulation Size Price (USD)  
Image RQ6357 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 429
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Flow cytometry testing of human ThP-1 cells with GRB10 antibody at 1ug/million cells (blocked with goat sera); Red=cells alone, Green=isotype control, Blue= GRB10 antibody.
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Flow cytometry testing of human ThP-1 cells with GRB10 antibody at 1ug/million cells (blocked with goat sera); Red=cells alone, Green=isotype control, Blue= GRB10 antibody.
Western blot testing of 1) human HEK293, 2) human HeLa, 3) monkey COS-7, 4) human HepG2, 5) rat kidney and 6) rat NRK cell lysate with GRB10 antibody. Expected molecular weight: 58-70 kDa.
Availability 1-3 business days
Species Reactivity Human, Monkey, Rat
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG1
Clone Name 5H7
Purity Antigen affinity purified
Buffer Lyophilized from 1X PBS with 2% Trehalose
UniProt Q13322
Applications Western blot : 0.5-1ug/ml
Flow cytometry : 1-3ug/million cells
Limitations This GRB10 antibody is available for research use only.
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Description

GRB10, Growth factor receptor-bound protein 10, also known as insulin receptor-binding protein Grb-IR is a protein that in humans is encoded by the GRB10 gene. The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors(e.g., IGF1R and IGF2R). Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner. Alternatively spliced transcript variants encoding different isoforms have been identified.

Application Notes

Optimal dilution of the GRB10 antibody should be determined by the researcher.

Immunogen

Recombinant human protein (amino acids M1-K251) was used as the immunogen for the GRB10 antibody.

Storage

After reconstitution, the GRB10 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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