GPX4 Antibody / Glutathione Peroxidase 4 (RQ8921)

Description

GPX4 (Glutathione Peroxidase 4) is a selenoprotein that protects cells against oxidative damage by reducing lipid hydroperoxides to their corresponding alcohols. It plays a central role in maintaining membrane integrity and preventing lipid peroxidation. Researchers frequently use a GPX4 antibody to study oxidative stress responses and redox regulation.

Unlike other glutathione peroxidases, GPX4 can directly reduce complex lipid hydroperoxides within membranes and lipoproteins, making it essential for cellular homeostasis. It has a critical role in ferroptosis, a form of regulated cell death driven by iron-dependent lipid peroxidation. Employing a GPX4 antibody enables the investigation of its unique function in cell survival and death pathways.

NSJ Bioreagents provides a high-quality GPX4 antibody validated for applications including western blot, immunohistochemistry, and immunofluorescence. Using a GPX4 antibody ensures reproducible and sensitive detection in studies of oxidative stress, ferroptosis, and disease mechanisms.

Application Notes

Optimal dilution of the GPX4 antibody should be determined by the researcher.

Immunogen

Amino acids A30-F197 of human Glutathione Peroxidase 4 were used as the immunogen for the GPX4 antibody.

Storage

After reconstitution, the GPX4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.