- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
GPRC5A Antibody / G-protein coupled receptor family C group 5 member A (FY12976)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
FY12976 | Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml | 100 ug | 439 |
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GPRC5A antibody detects G-protein coupled receptor family C group 5 member A, a retinoic acid-inducible orphan receptor involved in epithelial differentiation, inflammation, and tumor suppression. The UniProt recommended name is G-protein coupled receptor family C group 5 member A (GPRC5A), also known as retinoic acid-induced protein 3 (RAI3). This membrane receptor belongs to the class C GPCR family but lacks a known endogenous ligand, functioning primarily as a signaling modulator in epithelial cells.
Functionally, GPRC5A antibody identifies a 358-amino-acid transmembrane receptor localized to the plasma membrane and endosomal compartments. GPRC5A expression is strongly induced by retinoic acid and contributes to maintaining epithelial integrity and differentiation. It modulates multiple signaling pathways including EGFR, STAT3, and NF-kappaB, thereby influencing cell growth, polarity, and immune responses. Through its regulatory functions, GPRC5A acts as a context-dependent tumor suppressor in lung, pancreatic, and colorectal tissues.
The GPRC5A gene is located on chromosome 12p13.1 and is highly expressed in lung epithelium, gastrointestinal tract, and pancreas. In normal tissues, GPRC5A helps maintain epithelial homeostasis by dampening inflammatory and growth-promoting signals. Loss of GPRC5A expression has been implicated in lung adenocarcinoma and other epithelial cancers, where its absence leads to hyperactivation of EGFR and STAT3 pathways. Conversely, aberrant overexpression in certain cancers may promote proliferation and resistance to apoptosis.
In cell signaling, GPRC5A interacts with adaptor proteins to modulate receptor internalization and trafficking. It influences the balance between pro-inflammatory and anti-inflammatory signaling, acting as a mediator of cytokine responses in epithelial cells. GPRC5A also participates in differentiation processes during lung development and regeneration following injury, making it a valuable marker for epithelial cell identity and repair mechanisms.
GPRC5A antibody is used extensively in cancer biology, signal transduction, and epithelial cell research. It is applicable for immunoblotting, immunohistochemistry, and flow cytometry to evaluate receptor expression patterns and localization. In oncology, GPRC5A serves as a biomarker for tumor progression and epithelial transformation. Its detection aids in understanding the cross-talk between retinoic acid signaling and oncogenic pathways.
Structurally, GPRC5A possesses seven transmembrane helices typical of GPCRs, with an extracellular N-terminus and intracellular C-terminal domain involved in signaling interactions. It lacks a known G-protein coupling profile, suggesting atypical regulatory mechanisms through scaffolding proteins. NSJ Bioreagents provides GPRC5A antibody reagents validated for research in GPCR biology, epithelial signaling, and cancer progression.
Optimal dilution of the GPRC5A antibody should be determined by the researcher.
A synthetic peptide corresponding to a sequence in the middle region of human RAI3/GPRC5A was used as the immunogen for the GPRC5A antibody.
After reconstitution, the GPRC5A antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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