- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
GPD1 Antibody / Glycerol-3-phosphate dehydrogenase 1 (FY12648)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
FY12648 | Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml | 100 ug | 439 |
GPD1 antibody detects Glycerol-3-phosphate dehydrogenase 1, a cytosolic enzyme that catalyzes the reversible conversion of dihydroxyacetone phosphate to glycerol-3-phosphate, linking carbohydrate metabolism with lipid biosynthesis and energy regulation. GPD1 plays a crucial role in maintaining redox balance and metabolic flexibility. The GPD1 antibody is widely used in metabolic, biochemical, and endocrinological research to study lipid metabolism, redox cycling, and adipocyte differentiation.
GPD1 is encoded by the GPD1 gene located on human chromosome 12q13.12. The protein is approximately 349 amino acids long and localizes primarily in the cytoplasm. GPD1 functions in concert with its mitochondrial counterpart, GPD2, as part of the glycerophosphate shuttle that transfers reducing equivalents from NADH in the cytosol to the mitochondria for oxidative phosphorylation.
The GPD1 antibody detects a 37 kilodalton protein by western blot and shows cytosolic localization under immunofluorescence microscopy. GPD1 activity supports triglyceride synthesis in adipocytes and provides glycerol-3-phosphate as a substrate for lipid esterification. In muscle and liver, GPD1 contributes to energy metabolism by linking glycolysis to oxidative phosphorylation. Its regulation is sensitive to hormonal cues, including insulin and glucagon, and is modulated by redox state and nutrient availability.
Deficiency of GPD1 results in transient hypertriglyceridemia and hepatic steatosis due to impaired lipid processing. Genetic mutations have been associated with congenital lipodystrophy and metabolic syndrome. Increased GPD1 expression in adipose tissue correlates with obesity and insulin resistance, highlighting its importance in metabolic homeostasis.
Beyond energy metabolism, GPD1 influences cell signaling through regulation of NAD+/NADH balance and oxidative stress. It plays roles in thermogenesis, adipocyte differentiation, and lipid droplet biogenesis. NSJ Bioreagents provides a validated GPD1 antibody optimized for western blot, immunohistochemistry, and metabolic research, supporting studies into redox regulation, lipid metabolism, and energy homeostasis.
Optimal dilution of the GPD1 antibody should be determined by the researcher.
A synthetic peptide corresponding to a sequence at the N-terminus of human GPD1 was used as the immunogen for the GPD1 antibody.
After reconstitution, the GPD1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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