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Home >> Antibodies >> GP2 Antibody / Glycoprotein 2 / ZAP75

GP2 Antibody / Glycoprotein 2 / ZAP75 [clone GP2/1712] (V3333)

  Catalog No Formulation Size Price (USD)  
V3333-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 100 ug 429

V3333-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 20 ug 199

V3333SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 429
IHC testing of FFPE human pancreas with GP2 antibody (clone GP2/1712). HIER: boil tissue sections in 10mM Tris with 1mM EDTA, pH 9, for 10-20 min.
Availability 1-3 business days
Species Reactivity Human. Does not react with mouse. Other species not known.
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG2b, lambda
Clone Name GP2/1712
Purity Protein G affinity chromatography
UniProt P55259
Localization Cytoplasmic, membranous, secreted
Applications Flow Cytometry : 0.5-1ug/10e6 cells in 0.1ml
Immunofluorescence : 0.5-1ug/ml
Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT
Limitations This GP2 antibody is available for research use only.
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Description

GP2 (Glycoprotein 2), also known as ZAP75, is a 537 amino acid secreted protein. It is an integral membrane protein that is secreted from intracellular zymogen granules and associates with the plasma membrane via glycosylphosphatidylinositol (GPI) linkage. GP2 is cleaved and then released into the pancreatic duct along with exocrine secretions. GP2 binds pathogens such as enterobacteria, thereby playing an important role in the innate immune response. The C-terminus of this protein is related to the C-terminus of the protein encoded by the neighboring gene, uromodulin (UMOD). GP2 is also expressed on the apical plasma membrane of specialized microfold (M) cells among enterocytes and serves as a transcytotic receptor for mucosal antigens. M cells are considered a promising target for oral vaccination against various infectious diseases.

Application Notes

Optimal dilution of the GP2 antibody should be determined by the researcher.

Immunogen

A partial human recombinant protein corresponding to amino acids 35-179 was used as the immunogen for the GP2 antibody.

Storage

Store the GP2 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

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