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Home >> Antibodies >> GNS Antibody / Glucosamine (N-acetyl)-6-sulfatase

GNS Antibody / Glucosamine (N-acetyl)-6-sulfatase (RQ4270)

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  Catalog No Formulation Size Price (USD)  
Image RQ4270 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 429
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Western blot testing of human 1) HepG2, 2) PANC-1 and 3) SGC-7901 cell lysate with GNS antibody at 0.5ug/ml. Predicted molecular weight ~62 kDa, can be observed at ~94 kDa.
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Western blot testing of human 1) HepG2, 2) PANC-1 and 3) SGC-7901 cell lysate with GNS antibody at 0.5ug/ml. Predicted molecular weight ~62 kDa, can be observed at ~94 kDa.
Western blot testing of rat 1) lung, 2) kidney, 3) testis, 4) PC-12 lysate and mouse 5) lung, 6) kidney, 7) testis, 8) spleen and 9) thymus lysate with GNS antibody at 0.5ug/ml. Predicted molecular weight ~62 kDa, can be observed at ~94 kDa.
Availability 1-3 business days
Species Reactivity Human, Mouse, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity purified
Buffer Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
UniProt P15586
Localization Lysosome
Applications Western blot : 0.5-1ug/ml
Direct ELISA : 0.1-0.5ug/ml
Limitations This GNS antibody is available for research use only.
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Description

N-acetylglucosamine-6-sulfatase, also known as glucosamine (N-acetyl)-6-sulfatase, is an enzyme that in humans is encoded by the GNS gene. The product of this gene is a lysosomal enzyme found in all cells. It is involved in the catabolism of heparin, heparan sulphate, and keratan sulphate. Deficiency of this enzyme results in the accumulation of undegraded substrate and the lysosomal storage disorder mucopolysaccharidosis type IIID (Sanfilippo D syndrome). Mucopolysaccharidosis type IIID is the least common of the four subtypes of Sanfilippo syndrome.

Application Notes

Optimal dilution of the GNS antibody should be determined by the researcher.

Immunogen

A recombinant human protein corresponding to amino acids W238-R355 was used as the immunogen for the GNS antibody.

Storage

After reconstitution, the GNS antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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