- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
GNAQ Antibody / Guanine nucleotide binding protein Gq subunit alpha [clone 30G74] (FY12887)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
FY12887 | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA | 100 ul | 439 |
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GNAQ antibody detects Guanine nucleotide binding protein Gq subunit alpha, encoded by the GNAQ gene. This protein is a member of the heterotrimeric G protein alpha subunit family and couples receptors to downstream signaling cascades. Upon activation by G protein coupled receptors, GNAQ activates phospholipase C beta, leading to the production of inositol triphosphate and diacylglycerol. GNAQ antibody enables detailed study of this central signaling node and its contribution to cellular communication, growth, and differentiation.
Guanine nucleotide binding protein Gq subunit alpha plays a pivotal role in calcium signaling, activating pathways that regulate smooth muscle contraction, secretion, and gene expression. Dysregulation of GNAQ activity has been linked to developmental disorders, vascular anomalies, and cancers. Mutations in GNAQ are frequent in uveal melanoma and Sturge Weber syndrome, where they drive aberrant MAPK signaling and cell proliferation. Research using GNAQ antibody provides a means to detect altered protein levels and examine how mutant forms disrupt signaling dynamics.
Studies have also shown that GNAQ interacts with multiple effector pathways, including protein kinase C and Rho GTPases, extending its impact on cytoskeletal remodeling, migration, and survival. GNAQ antibody has been used to investigate signaling crosstalk in cardiovascular, neurological, and oncological contexts. Its function in coupling receptors to intracellular calcium release makes it indispensable for understanding receptor mediated physiology and pathology.
GNAQ antibody is employed in western blotting, immunohistochemistry, and immunofluorescence. Western blotting measures expression in tissues such as brain, heart, and smooth muscle. Immunohistochemistry visualizes localization in vascular endothelium and tumor samples. Immunofluorescence reveals distribution at the plasma membrane, consistent with its role as a receptor coupled G protein. Functional experiments have used GNAQ antibody to track expression changes following pharmacological inhibition of GPCR pathways.
By providing validated GNAQ antibody reagents, NSJ Bioreagents supports research in receptor signaling, cancer biology, and cardiovascular physiology. Guanine nucleotide binding protein Gq subunit alpha remains a vital component of GPCR signaling pathways, and detection with GNAQ antibody ensures reliable insights into its regulation and disease relevance.
Optimal dilution of the GNAQ antibody should be determined by the researcher.
A synthesized peptide derived from human GNAQ was used as the immunogen for the GNAQ antibody.
Store the GNAQ antibody at -20oC.
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