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Home >> Antibodies >> Glucokinase Antibody / GCK

Glucokinase Antibody / GCK (RQ4053)

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  Catalog No Formulation Size Price (USD)  
Image RQ4053 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 429
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Western blot testing of 1) rat liver and 2) mouse liver lysate with Glucokinase antibody at 0.5ug/ml. Predicted molecular weight ~52 kDa.
Western blot testing of 1) rat liver and 2) mouse liver lysate with Glucokinase antibody at 0.5ug/ml. Predicted molecular weight ~52 kDa.
Availability 1-3 business days
Species Reactivity Human, Mouse, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity purified
Buffer Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
UniProt P35557
Applications Western Blot : 0.5-1ug/ml
Direct ELISA : 0.1-0.5ug/ml
Limitations This Glucokinase antibody is available for research use only.
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Description

Glucokinase (GCK) is an enzyme that facilitates phosphorylation of glucose to glucose-6-phosphate. Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).

Application Notes

Optimal dilution of the Glucokinase antibody should be determined by the researcher.

Immunogen

A recombinant human partial protein corresponding to amino acids Y234-T431 was used as the immunogen for the Glucokinase antibody.

Storage

After reconstitution, the Glucokinase antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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