- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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GLRX2 Antibody / Glutaredoxin-2 Mitochondrial Protein Antibody recognizes glutaredoxin-2, a member of the glutaredoxin family of small oxidoreductases involved in maintaining cellular redox homeostasis. Encoded by the GLRX2 gene, glutaredoxin-2 participates in glutathione-dependent thiol-disulfide exchange reactions and helps regulate the oxidation state of protein cysteine residues. Its activity connects the glutathione redox system with cellular responses to oxidative stress and changes in metabolic state.
GLRX2 is particularly associated with mitochondrial redox regulation. The protein contains an iron-sulfur cluster that can influence its activity and allows glutaredoxin-2 to respond to changes in the cellular redox environment. Under oxidative conditions, activation of GLRX2 can promote reversible protein deglutathionylation and help restore the function of redox-sensitive proteins. These properties distinguish GLRX2 from classical glutaredoxins and support its role in protecting mitochondrial proteins against oxidative modification.
Alternative transcription and splicing of GLRX2 generate isoforms with different intracellular distributions. The mitochondrial form contains an N-terminal targeting sequence that directs the protein to mitochondria, whereas other GLRX2 isoforms can occur outside the organelle. This isoform diversity allows glutaredoxin-2 activity to contribute to redox control in multiple cellular compartments while maintaining an especially important relationship with mitochondrial function.
Within mitochondria, GLRX2 has been investigated for its involvement in respiratory function, redox-sensitive signaling, cellular energy metabolism, and protection from oxidative stress. By regulating reversible protein glutathionylation, GLRX2 can influence proteins whose activities depend upon the oxidation state of critical cysteine residues. Its relationship with mitochondrial redox balance has also generated interest in the protein in studies of cell survival, metabolic regulation, oxidative injury, and disease-associated changes in mitochondrial physiology.
NSJ Bioreagents offers this Glutaredoxin-2 Mitochondrial Protein Antibody for research into GLRX2 expression and redox biology. A GLRX2 Antibody can support investigation of mitochondrial redox regulation, glutathione-dependent protein modification, oxidative stress responses, and mechanisms that maintain cellular redox homeostasis.
Explore our Mitochondria Marker Antibody page for additional reagents targeting proteins involved in mitochondrial function, metabolism, redox regulation, and cellular homeostasis.
Optimal dilution of the GLRX2 Antibody / Glutaredoxin-2 Mitochondrial Protein Antibody should be determined by the researcher.
A human recombinant partial protein (amino acids M1-Q164) was used as the immunogen for the GLRX2 antibody.
After reconstitution, the GLRX2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
GLRX2 antibody, Glutaredoxin-2 antibody, Glutaredoxin 2 antibody, GRX2 antibody, Glutaredoxin-2 mitochondrial antibody, Mitochondrial glutaredoxin-2 antibody
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