- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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GJB1 Antibody / Gap Junction Beta-1 Protein Antibody recognizes GJB1, the gene encoding Gap Junction Beta-1 Protein, more commonly known as Connexin 32 (Cx32). GJB1 belongs to the connexin family of transmembrane proteins that assemble into gap junction channels, allowing adjacent cells to exchange ions, metabolites, and other small signaling molecules. Six GJB1 protein subunits oligomerize to form a connexon, or hemichannel, which pairs with a connexon on a neighboring cell to establish a functional gap junction. These channels are essential for coordinated cellular communication, tissue homeostasis, and the maintenance of normal physiological function in numerous organs.
Gap Junction Beta-1 Protein is highly expressed in hepatocytes, Schwann cells, pancreatic acinar cells, renal tubular epithelium, and other epithelial tissues. Within the peripheral nervous system, GJB1 facilitates radial diffusion of ions and metabolites through compact myelin, supporting axonal maintenance and normal nerve conduction. In the liver, it represents the predominant connexin isoform and plays a central role in coordinating metabolic activity, regeneration, and responses to cellular injury. Expression and channel activity are regulated through phosphorylation, intracellular trafficking, and gap junction turnover, enabling tissues to rapidly adapt intercellular communication in response to physiological and pathological stimuli.
Mutations in the GJB1 gene are responsible for X-linked Charcot-Marie-Tooth disease type 1, one of the most common inherited peripheral neuropathies. Many pathogenic variants impair gap junction assembly, intracellular transport, or channel permeability, resulting in progressive demyelination, muscle weakness, and sensory deficits. Beyond inherited neuropathies, altered GJB1 expression has been associated with hepatocellular carcinoma, pancreatic cancer, liver injury, inflammatory disorders, and other diseases characterized by disrupted gap junction communication. Consequently, GJB1 remains an important research target in neuroscience, hepatology, oncology, and studies of intercellular signaling.
A GJB1 Antibody is a valuable research tool for investigating gap junction biology, cell-cell communication, peripheral neuropathies, liver physiology, and diseases involving altered connexin function.
For a broader overview of Connexin 32 biology, gap junction function, and intercellular communication, see our Connexin 32 Antibody / Cx32 Antibody page.
Optimal dilution of the GJB1 Antibody / Gap Junction Beta-1 Protein Antibody should be determined by the researcher.
E. coli-derived recombinant human protein (amino acids A92-A147) was used as the immunogen for the GJB1 antibody.
After reconstitution, the GJB1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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