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Home >> Antibodies >> GITR Antibody (TNFRSF18)

GITR Antibody (TNFRSF18) [clone DTA-1] (V3050)

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  Catalog No Formulation Size Price (USD)  
Image V3050-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 100 ug 519
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V3050-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 20 ug 229
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V3050SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
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SDS-PAGE Analysis of Purified, BSA-Free GITR Antibody (clone DTA-1). Confirmation of Integrity and Purity of the Antibody.
SDS-PAGE Analysis of Purified, BSA-Free GITR Antibody (clone DTA-1). Confirmation of Integrity and Purity of the Antibody.
Availability 1-3 business days
Species Reactivity Mouse
Format Purified
Clonality Monoclonal (rat origin)
Isotype Rat IgG2b, lambda
Clone Name DTA-1
Purity Protein G affinity chromatography
UniProt O35714 (Mouse)
Localization Secreted, cell surface
Applications Flow cytometry : 0.5-1ug/10^6 cells
Immunofluorescence : 0.5-1ug/ml
Limitations This GITR antibody is available for research use only.
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Description

GITR (glucocorticoid-induced TNFR-related gene) is a member of the TNF-receptor superfamily, also known as TNFRSF18. It is expressed at low levels on resting T lymphocytes and at high levels on CD25+ CD4+ Tregs. The expression of GITR on T cells can be upregulated upon activation. Interaction of GITR with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production as well as MAPKs and NF-kB activation, and abrogate the inhibitory function of CD25+ CD4+ Tregs. In vivo activation of GITR causes development of autoimmune diseases and restores the suppressed immune response.

Application Notes

Optimal dilution of the GITR antibody should be determined by the researcher.

Immunogen

Mouse CD25+ CD4+ T cells were used as the immunogen for the GITR antibody.

Storage

Store the GITR antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

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