- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
GIP Antibody / Incretin Hormone Antibody (R32434)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
R32434 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 449 |
| Availability | 1-3 business days |
| Species Reactivity | Human, Rat |
| Format | Antigen affinity purified |
| Host | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Antigen affinity |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose |
| UniProt | P09681 |
| Applications | Western Blot : 0.5-1ug/ml Immunohistochemistry (FFPE) : 2-5ug/ml |
| Limitations | This GIP Antibody / Incretin Hormone Antibody is available for research use only. |
|
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GIP Antibody / Incretin Hormone Antibody is designed to detect glucose-dependent insulinotropic polypeptide (GIP), an important peptide hormone that regulates postprandial glucose homeostasis and energy metabolism. GIP is synthesized primarily by enteroendocrine K cells of the proximal small intestine and is released into the circulation in response to nutrient ingestion, particularly carbohydrates and fats. As one of the body's principal incretin hormones, GIP stimulates glucose-dependent insulin secretion from pancreatic beta cells while coordinating communication between the gastrointestinal tract and the endocrine pancreas. Because of its central role in nutrient sensing and metabolic regulation, GIP has become an important target in diabetes, obesity, and metabolic disease research. A GIP Antibody / Incretin Hormone Antibody enables researchers to investigate hormone expression, tissue localization, and changes in GIP production across physiological and pathological conditions.
Following secretion, GIP binds to the GIP receptor, a G protein-coupled receptor expressed on pancreatic beta cells and numerous other tissues including adipose tissue, bone, and the central nervous system. Activation of GIP receptor signaling enhances cyclic AMP production, promotes insulin release during hyperglycemia, and influences lipid metabolism, bone remodeling, and cellular energy balance. While initially recognized for its insulinotropic activity, GIP is now understood to have broader physiological functions involving appetite regulation, adipocyte biology, and interactions with other metabolic hormones such as glucagon-like peptide 1. These diverse biological activities have generated considerable interest in GIP signaling pathways as researchers seek to better understand endocrine regulation and whole-body metabolic homeostasis. Consequently, a GIP Antibody / Incretin Hormone Antibody is valuable for studying incretin biology in both experimental models and clinical research specimens.
Altered GIP signaling has been associated with type 2 diabetes, obesity, insulin resistance, metabolic syndrome, and cardiovascular disease. In individuals with diabetes, impaired responsiveness to GIP contributes to diminished insulin secretion despite preserved hormone production. More recently, pharmacological agents targeting both GIP and glucagon-like peptide 1 receptors have demonstrated promising therapeutic effects for improving glycemic control and promoting weight loss, further increasing scientific interest in this signaling pathway. Beyond metabolic disorders, GIP has also been investigated in bone metabolism, neurobiology, gastrointestinal physiology, and inflammatory processes. Accurate detection of GIP expression therefore supports studies examining hormone regulation, endocrine adaptation, therapeutic mechanisms, and disease-associated alterations in incretin signaling across multiple organ systems.
GIP Antibody / Incretin Hormone Antibody is suitable for applications including immunohistochemistry, immunofluorescence, Western blotting, immunoprecipitation, and other protein detection methods, depending on individual antibody validation. NSJ Bioreagents provides carefully validated antibodies to support investigations of endocrine physiology, gastrointestinal biology, metabolic regulation, diabetes research, and hormone signaling pathways. An GIP Antibody / Incretin Hormone Antibody is a valuable research reagent for detecting glucose-dependent insulinotropic polypeptide and advancing studies of incretin biology, insulin secretion, energy homeostasis, and metabolic disease.
Explore our Metabolism Antibodies page to discover validated antibodies for GIP and other proteins involved in glucose homeostasis, insulin secretion, incretin signaling, energy metabolism, obesity, and metabolic disease research.
Optimal dilution of the GIP Antibody / Incretin Hormone Antibody should be determined by the researcher.
Amino acids Y52-Q93 from the human protein were used as the immunogen for the GIP antibody.
After reconstitution, the GIP antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
GIP antibody, glucose-dependent insulinotropic polypeptide antibody, gastric inhibitory polypeptide antibody, gastric inhibitory peptide antibody, incretin hormone antibody
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