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Home >> Antibodies >> GIP Antibody / Gastric inhibitory polypeptide

GIP Antibody / Gastric inhibitory polypeptide (R32434)

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  Catalog No Formulation Size Price (USD)  
Image R32434 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 429
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Western blot testing of human MCF7 cell lysate with GIP antibody. Expected molecular weight ~17 kDa.
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Western blot testing of human MCF7 cell lysate with GIP antibody. Expected molecular weight ~17 kDa.
IHC testing of FFPE human pancreatic cancer tissue with GIP antibody. HIER: Boil the paraffin sections in pH 6, 10mM citrate buffer for 20 minutes and allow to cool prior to testing.
Availability 1-3 business days
Species Reactivity Human
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
UniProt P09681
Applications Western blot : 0.1-0.5ug/ml
IHC (FFPE) : 0.5-1ug/ml
Limitations This GIP antibody is available for research use only.
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Description

Gastric inhibitory polypeptide (GIP), also known as the glucose-dependent insulinotropic peptide, is an inhibiting hormone of the secretin family of hormones. GIP is thought to have significant effects on fatty acid metabolism through stimulation of lipoprotein lipase activity in adipocytes. Additionally, GIP release has been demonstrated in the ruminant animal and may play a role in nutrient partitioning in milk production (lipid metabolism). Recently, GIP appeared as a major player in bone remodelling. It was evidenced that genetic ablation of the GIP receptor in mice resulted in profound alterations of bone microarchitecture through modification of the adipokine network. Furthermore, the deficiency in GIP receptors has also been associated in mice with a dramatic decrease in bone quality and a subsequent increase in fracture risk.

Application Notes

Optimal dilution of the GIP antibody should be determined by the researcher.

Immunogen

Amino acids Y52-Q93 from the human protein were used as the immunogen for the GIP antibody.

Storage

After reconstitution, the GIP antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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