- Tel: 858.663.9055
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
GHR Antibody / Growth Hormone Receptor [clone 17G57] (RQ5338)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
 |
RQ5338 | Antibody in PBS with 0.02% sodium azide and 50% glycerol | 100 ul | 429 |
|
| Availability | 1-2 weeks |
| Species Reactivity | Human, Mouse |
| Format | Purified |
| Clonality | Rabbit Monoclonal |
| Isotype | Rabbit IgG |
| Clone Name | 17G57 |
| Purity | Affinity purified |
| UniProt | P10912 |
| Applications | Western blot : 1:500-1:2000 |
| Limitations | This GHR antibody is available for research use only. |
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The GHR gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene. [RefSeq]
Optimal dilution of the GHR antibody should be determined by the researcher.
A synthetic peptide specific to human Growth Hormone Receptor / GHR was used as the immunogen for the GHR antibody.
Store the GHR antibody at -20oC.
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