- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
GGCT Antibody / Gamma-glutamylcyclotransferase (FY12401)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
FY12401 | Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml | 100 ug | 439 |
The GGCT antibody targets Gamma-glutamylcyclotransferase, an enzyme encoded by the GGCT gene that participates in glutathione metabolism and cellular antioxidant defense. Gamma-glutamylcyclotransferase catalyzes the conversion of gamma-glutamyl amino acids to 5-oxoproline and free amino acids, playing a vital role in the gamma-glutamyl cycle. This pathway is central to maintaining intracellular glutathione levels and protecting cells from oxidative damage. The GGCT antibody provides researchers with a reliable reagent for studying redox balance, metabolic regulation, and stress response mechanisms.
Gamma-glutamylcyclotransferase localizes primarily to the cytosol, where it regulates the degradation of glutathione conjugates. By catalyzing gamma-glutamyl bond cleavage, the enzyme supports the recycling of amino acids used for glutathione synthesis. The GGCT antibody enables visualization and quantification of this enzyme in cells and tissues, supporting research into oxidative stress–related pathways and cellular detoxification processes. Through its activity, GGCT contributes to maintaining redox homeostasis and protecting against reactive oxygen species (ROS) accumulation.
Upregulation of Gamma-glutamylcyclotransferase has been reported in various cancers, including breast, lung, and bladder tumors, where it is associated with enhanced proliferation and stress resistance. Elevated GGCT expression supports tumor growth by maintaining redox stability and promoting metabolic flexibility. The GGCT antibody is used to investigate these oncogenic functions, providing insight into how altered glutathione metabolism contributes to tumorigenesis. It also enables assessment of GGCT as a potential biomarker or therapeutic target in oxidative stress–driven cancers.
Beyond cancer, Gamma-glutamylcyclotransferase plays roles in neuroprotection and metabolic adaptation. Its regulation affects glutathione turnover in the brain, liver, and kidneys, influencing detoxification capacity and antioxidant defense. The GGCT antibody allows researchers to track expression changes in response to nutritional status, xenobiotic exposure, and oxidative injury. Dysregulation of GGCT may contribute to neurodegenerative diseases and metabolic disorders characterized by redox imbalance.
The GGCT antibody performs effectively in western blotting, immunofluorescence, and immunohistochemistry, showing strong cytoplasmic staining consistent with its enzymatic localization. NSJ Bioreagents provides this antibody with validated specificity and reproducibility for biochemistry, oncology, and redox biology research. By enabling accurate detection of Gamma-glutamylcyclotransferase, the GGCT antibody supports studies into glutathione metabolism, oxidative stress, and disease-related metabolic reprogramming.
Optimal dilution of the GGCT antibody should be determined by the researcher.
E.coli-derived human GGCT recombinant protein (Position: N25-L188) was used as the immunogen for the GGCT antibody.
After reconstitution, the GGCT antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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