- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Gdf15 Antibody / Growth differentiation factor 15 (FY13353)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
FY13353 | Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml | 100 ug | 439 |
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GDF15 antibody detects Growth differentiation factor 15, a secreted cytokine belonging to the transforming growth factor beta superfamily. The GDF15 gene is located on chromosome 19p13.11 and encodes a stress-responsive protein that regulates inflammation, metabolism, and cellular stress adaptation. GDF15 is highly expressed in liver, placenta, prostate, and macrophages, and its expression increases dramatically in response to cellular injury, hypoxia, or mitochondrial dysfunction. It plays a central role in energy homeostasis, appetite regulation, and tissue repair through endocrine and paracrine mechanisms.
GDF15 is synthesized as a precursor protein that undergoes proteolytic cleavage to release a mature disulfide-linked dimer. It exerts its biological effects primarily through binding to the GDNF family receptor alpha-like (GFRAL) receptor in the brainstem, which, together with RET co-receptor, mediates appetite suppression and energy expenditure. In peripheral tissues, GDF15 influences macrophage activation, anti-inflammatory responses, and tissue protection under stress. Co-localization studies show GDF15 present in secretory vesicles of hepatocytes and trophoblasts, as well as circulating in plasma as a stable cytokine dimer.
Structurally, GDF15 shares conserved cysteine residues and dimerization motifs characteristic of the transforming growth factor beta family. It forms a homodimeric structure essential for receptor binding and downstream signaling activation. GDF15 belongs to the growth differentiation factor family, which includes GDF11, GDF8 (myostatin), and GDF9, all of which regulate growth and differentiation processes. Known interacting partners include GFRAL, RET, and transforming growth factor beta receptors in certain contexts.
Functionally, GDF15 acts as a key regulator of systemic metabolism and cellular stress response. It suppresses appetite and body weight through the GFRAL-RET signaling axis in the central nervous system while also promoting tissue tolerance to metabolic stress. In macrophages and endothelial cells, GDF15 has anti-inflammatory effects, limiting excessive immune activation. In the cardiovascular system, GDF15 protects against ischemic injury by reducing apoptosis and oxidative stress. During embryonic development, it is expressed in placenta and plays roles in implantation and trophoblast differentiation.
Dysregulation of GDF15 expression is associated with numerous pathological conditions. Elevated circulating levels occur in cancer, obesity, cardiovascular disease, and mitochondrial disorders, where GDF15 serves as a biomarker of cellular stress. In oncology, high GDF15 promotes cachexia and tumor progression via immune and metabolic pathways. Conversely, GDF15 has protective effects in metabolic diseases by improving glucose tolerance and reducing inflammation. Pathway involvement includes transforming growth factor beta signaling, mitochondrial stress response, and energy metabolism regulation.
Immunohistochemical staining using GDF15 antibody shows cytoplasmic and extracellular localization in hepatocytes, macrophages, and placental trophoblasts. The GDF15 antibody from NSJ Bioreagents is ideal for studies involving stress signaling, metabolism, and cytokine biology.
Optimal dilution of the Gdf15 antibody should be determined by the researcher.
E.coli-derived mouse Gdf15 recombinant protein (Position: S189-A302) was used as the immunogen for the Gdf15 antibody.
After reconstitution, the Gdf15 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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