- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
GCSAM Antibody / Germinal Center Signaling Antibody [clone HGAL/2373] (V9452)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V9452-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
|
V9452-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
|
|
V9452SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG2b, kappa |
| Clone Name | HGAL/2373 |
| Purity | Protein A/G affinity |
| UniProt | Q8N6F7 |
| Localization | Cytoplasm, Cell membrane |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This GCSAM Antibody / Germinal Center Signaling Antibody is available for research use only. |
|
Review this product on BioCompare and get a $20 Amazon gift card
|
Related Products
|
Germinal center-associated signaling and motility protein (GCSAM), commonly known as HGAL, is a cytoplasmic signaling-associated protein involved in regulation of lymphocyte motility, cytoskeletal organization, B-cell differentiation, and germinal center-associated immune signaling pathways. GCSAM expression is strongly associated with germinal center B lymphocytes and subsets of lymphoma-associated cellular populations, where it contributes to adaptive immune organization and lymphoid differentiation-associated signaling networks. GCSAM Antibody is useful for investigations involving germinal center biology, lymphoma-associated signaling, hematopathology, and B-cell lineage differentiation pathways.
GCSAM antibody, also referred to as HGAL antibody, Germinal center-associated signaling and motility antibody, and GCET2 antibody in the literature, recognizes a cytoplasmic protein encoded on chromosome 3q13.2. GCSAM localizes predominantly to germinal center-associated B-cell populations where it participates in signaling pathways regulating cellular migration, actin-associated cytoskeletal remodeling, and immune microenvironment organization. Expression of GCSAM is strongly associated with follicular lymphoma and germinal center-associated diffuse large B-cell lymphoma subtypes.
GCSAM Antibody / Germinal Center Signaling Antibody (clone HGAL/2373) is uniquely positioned for studies involving lymphoma-associated signaling and germinal center-associated cellular organization. This mouse monoclonal antibody demonstrates strong immunohistochemical detection together with HuProt(TM) microarray specificity validation against more than 19,000 full-length human proteins. The combined validation profile supports use of clone HGAL/2373 in investigations involving germinal center-associated signaling regulation, B-cell differentiation pathways, and lymphoma-associated immune organization.
Analysis of HuProt(TM) microarrays containing more than 19,000 individually purified full-length human proteins demonstrated highly selective recognition of GCSAM/HGAL by clone HGAL/2373. In HuProt(TM) analysis, the Z-score represents the strength of antibody binding signal relative to the overall array mean, while the S-score reflects target specificity relative to the next highest ranked protein signal. Elevated S-score separation supports preferential target recognition and reduced off-target binding across the tested human proteome. This specificity validation approach is valuable in studies involving heterogeneous lymphoid tissues and hematopathology-associated cellular populations.
GCSAM contributes to regulation of lymphocyte migration and germinal center-associated immune signaling through interactions involving cytoskeletal regulatory pathways and B-cell receptor-associated signaling networks. Altered expression of GCSAM has been associated with lymphoma-associated differentiation states, immune microenvironment organization, and germinal center-associated tumor biology. Because GCSAM expression is highly enriched in germinal center-associated B-cell populations, it serves as a useful marker for investigations involving lymphoid differentiation and lymphoma-associated signaling regulation.
This GCSAM Antibody supports research involving germinal center signaling pathways, lymphoma-associated immune regulation, hematopathology, lymphocyte motility-associated signaling, adaptive immune organization, B-cell lineage differentiation, and cytoskeletal signaling-associated cellular regulation. Clone HGAL/2373 may be incorporated into immunohistochemistry and tissue-based investigations examining germinal center-associated immune differentiation in normal and diseased tissues.
For highly specific detection of germinal center-associated B-cell populations, see our HGAL Antibody / Germinal Center B-Cell Marker Antibody page featuring clone HGAL/2834 with IHC and HuProt(TM) microarray specificity validation data.
Optimal dilution of the GCSAM Antibody / Germinal Center Signaling Antibody should be determined by the researcher.
A portion of amino acids 1-200 was used as the immunogen for the GCSAM antibody.
Aliquot the GCSAM antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
GCSAM antibody, HGAL antibody, Germinal center-associated signaling and motility antibody, Germinal center signaling antibody, GCET2 antibody
Your bulk quote request has been submitted successfully!
Please contact us if you have any questions.
Powered by Bioz
