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Home >> Antibodies >> GCN5 Antibody / KAT2A

GCN5 Antibody / KAT2A (R32295)

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  Catalog No Formulation Size Price (USD)  
Image R32295 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 429
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Western blot testing of human 1) A431, 2) 22RV1 and 3) COLO320 lysate with GCN5 antibody. Expected/observed molecular weight ~94 kDa.
Western blot testing of human 1) A431, 2) 22RV1 and 3) COLO320 lysate with GCN5 antibody. Expected/observed molecular weight ~94 kDa.
Availability 1-3 business days
Species Reactivity Human
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
UniProt Q92830
Applications Western blot : 0.1-0.5ug/ml
Limitations This GCN5 antibody is available for research use only.
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Description

Histone acetyltransferase KAT2A, also called GCN5 and GCN5L2, is an enzyme that in humans is encoded by the KAT2A gene. It is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. The GCN5 protein, a regulator of transcription activation in yeast, promotes maximal levels of transcription by 2 transcriptional activators, GCN4 and the HAP2-HAP3-HAP4 complex. The GCN4 protein activates transcription of a large number of amino acid biosynthetic genes under limiting amino acid conditions and the HAP2-HAP3-HAP4 complex is thought to mediate transcription of genes involved in respiratory functions. GCN5 also functions as a repressor of NF-kappa-B by promoting ubiquitination of the NF-kappa-B subunit RELA in a HAT-independent manner.

Application Notes

Optimal dilution of the GCN5 antibody should be determined by the researcher.

Immunogen

Amino acids DPARPGLSQQQRASQRKAQVRGLPRAKKLEKL of human KAT2A/GCN5 were used as the immunogen for the GCN5 antibody.

Storage

After reconstitution, the GCN5 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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