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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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Group-specific component (GC), also known as Vitamin D binding protein (VDBP) or Gc-globulin, is a circulating plasma carrier protein involved in vitamin D metabolite transport, extracellular actin scavenging, and systemic endocrine homeostasis. The GC Antibody / Serum Gc-Globulin Antibody clone VDBP/9980 is designed for detection of GC expression in studies involving plasma transport physiology, hepatic secretory protein biology, endocrine metabolism, and circulating carrier-associated regulatory pathways.
GC is encoded by the GC gene on chromosome 4q13 and is synthesized predominantly by hepatocytes before secretion into plasma and extracellular fluids. The protein functions as the principal serum carrier for vitamin D and its metabolites, regulating systemic transport and bioavailability of endocrine signaling molecules associated with calcium homeostasis and metabolic regulation. Because GC circulates at high concentrations in serum, the protein serves as a major component of extracellular transport physiology and systemic metabolic homeostasis pathways.
Beyond vitamin D transport, GC participates in extracellular actin scavenging mechanisms that help maintain vascular and tissue integrity following cellular injury and inflammatory stress. The protein may also contribute to macrophage-associated immune signaling and inflammatory response pathways. Altered GC abundance has been associated with liver disease, kidney dysfunction, inflammatory disorders, metabolic abnormalities, and endocrine-associated physiologic imbalance.
GC has attracted substantial research interest across hepatology, endocrinology, nephrology, and clinical pathology due to its role as a liver-derived plasma transport protein. Because circulating GC levels may influence systemic vitamin D bioavailability and transport-associated endocrine signaling, the protein is frequently studied alongside markers of hepatic secretory function, metabolic regulation, and extracellular transport-associated physiology.
Immunohistochemical analysis using GC antibodies commonly demonstrates cytoplasmic staining patterns within hepatocyte-associated and epithelial tissue compartments consistent with the secretory biology of this circulating serum globulin. Expression within pancreatic and hepatic tissue environments further supports the role of GC in endocrine-associated metabolic physiology and systemic transport pathways.
GC continues to serve as an important target in studies involving plasma carrier proteins, serum transport physiology, vitamin D homeostasis, hepatic secretory biology, and endocrine metabolism. For broader analysis of vitamin D transport-associated endocrine signaling pathways, see our VDBP Antibody / Endocrine Vitamin D Transport Protein Antibody.
Optimal dilution of the GC Antibody / Serum Gc-Globulin Antibody should be determined by the researcher.
A portion of amino acids 1-200 from human Vitamin D binding protein was used as the immunogen for the GC antibody.
Aliquot the GC antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
GC antibody, Group-specific component antibody, Gc-globulin antibody, Plasma carrier protein antibody, Serum transport protein antibody
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