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Home >> Antibodies >> GC Antibody / Group specific component / VDBP

GC Antibody / Group specific component / VDBP [clone VDBP/9980] (V5711)

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  Catalog No Formulation Size Price (USD)  
Image V5711-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 539
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V5711-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 249
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V5711SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 539
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IHC staining of FFPE human pancreas tissue with GC antibody (clone VDBP/9980). Inset: PBS used in place of primary Ab (secondary Ab negative control). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
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IHC staining of FFPE human pancreas tissue with GC antibody (clone VDBP/9980). Inset: PBS used in place of primary Ab (secondary Ab negative control). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
IHC staining of FFPE human liver tissue with GC antibody (clone VDBP/9980). Inset: PBS used in place of primary Ab (secondary Ab negative control). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG, kappa
Clone Name VDBP/9980
Purity Protein A/G affinity
UniProt P02774
Localization Secreted
Applications Immunohistochemistry (FFPE) : 1-2ug/ml
Limitations This GC antibody is available for research use only.
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Description

Vitamin D-binding protein (DBP) is a multi-functional serum protein that binds to the plasma membranes of numerous cell types and mediates a variety of cellular functions. The locus of the DBP protein (also known as group-specific component protein or GC) is located at human chromosome 4q13.3. DBP functions in organ-specific transportation of vitamin D and its metabolites to the various target organs of the vitamin D endocrine system. In addition, DBP has immunomodulatory properties and is able to bind to the surface of leukocytes. DBP binds to the plasma membrane through a chondroitin sulfate proteoglycan. DBP serves as a co-chemotactic factor for C5a to enhance the chemotactic activity of C5a. DBP can also bind to globular Actin with high affinity and is involved in the clearance of Actin from the blood. DBP plays an important role in osteoclast differentiation. The diverse cellular functions of DBP require its cell surface binding ability to mediate different biological processes.

Application Notes

Optimal dilution of the GC antibody should be determined by the researcher.

Immunogen

A portion of amino acids 1-200 from human Vitamin D binding protein was used as the immunogen for the GC antibody.

Storage

Aliquot the GC antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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