- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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GBP2 Antibody / Interferon Induced GTPase Antibody recognizes guanylate binding protein 2 (GBP2), a member of the large GTPase family induced by interferons during innate immune activation. GBP2 is rapidly upregulated in response to type I and type II interferons, where it contributes to host defense by regulating antimicrobial and antiviral immune responses. As an interferon-responsive GTPase, GBP2 participates in pathogen restriction, inflammatory signaling and immune cell activation, making it an important target for immunology, infectious disease and cancer research. NSJ Bioreagents offers high-quality GBP2 Antibody reagents for investigating interferon-mediated signaling pathways and innate immunity.
GBP2 hydrolyzes guanosine triphosphate and associates with intracellular membranes, pathogen-containing vacuoles and signaling complexes following immune stimulation. It cooperates with other guanylate binding proteins and interferon-induced proteins to restrict the replication of intracellular bacteria, parasites and viruses while promoting activation of inflammasome pathways and antimicrobial defense mechanisms. Through these activities, GBP2 helps coordinate cell-autonomous immunity and contributes to the early innate immune response against invading pathogens. Consequently, GBP2 Antibody is widely used to study interferon signaling, host-pathogen interactions and inflammatory regulation.
Beyond infectious disease, GBP2 has emerged as a biomarker of immune activation within the tumor microenvironment. Elevated GBP2 expression has been associated with interferon signaling signatures, immune cell infiltration and responses to immunotherapy in several cancer types. In addition, GBP2 has been investigated in autoimmune disorders and chronic inflammatory diseases in which sustained interferon signaling contributes to disease pathogenesis. These diverse biological functions have established GBP2 as an important regulator linking innate immunity with inflammation and cancer biology.
An GBP2 Antibody is a valuable reagent for investigating interferon signaling, antimicrobial defense and innate immune regulation. An Interferon Induced GTPase Antibody supports research involving host-pathogen interactions, inflammatory signaling, antiviral immunity, tumor immunology and immune-mediated disease.
Researchers studying innate immunity, inflammatory signaling and host defense may also be interested in our Innate Immune Antibodies page, featuring antibodies against key regulators of antimicrobial and interferon-mediated immune responses.
Optimal dilution of the GBP2 Antibody / Interferon Induced GTPase Antibody should be determined by the researcher.
E.coli-derived human Guanylate binding protein 2 recombinant protein (amino acids G132-L480) was used as the immunogen for the GBP2 Antibody.
After reconstitution, the GBP2 Antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
GBP2 antibody, Interferon Induced GTPase antibody, Guanylate Binding Protein 2 antibody, Guanylate-Binding Protein 2 antibody
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