- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
GBA3 Antibody / Glucosidase beta acid 3 / Cytosolic beta-glucosidase (FY12274)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
FY12274 | Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml | 100 ug | 439 |
GBA3 antibody detects Cytosolic beta-glucosidase, encoded by the GBA3 gene on chromosome 4p15.33. GBA3 antibody is commonly used in carbohydrate metabolism, detoxification, and nutrition-related research. GBA3 is a cytosolic glycoside hydrolase that catalyzes the hydrolysis of beta-glycosidic bonds in various substrates, including plant-derived glycosides and dietary glucosides. Unlike lysosomal beta-glucosidases, GBA3 operates in the cytosol, processing exogenous and endogenous compounds.
Structurally, GBA3 is a ~54 kDa protein belonging to the glycosyl hydrolase family 1 (GH1). It contains a conserved catalytic domain with a (beta/alpha)8 barrel fold that accommodates diverse glycoside substrates. GBA3 is widely expressed in liver, kidney, and intestine, where it contributes to detoxification and carbohydrate processing.
Functionally, GBA3 hydrolyzes beta-glycosidic bonds in compounds such as cyanogenic glycosides and flavonoid glucosides. This activity detoxifies plant-derived compounds and releases bioactive aglycones. GBA3 also metabolizes certain drugs and xenobiotics, influencing pharmacokinetics. Researchers use GBA3 antibody to study carbohydrate metabolism, dietary compound processing, and xenobiotic metabolism.
Clinically, GBA3 activity influences metabolism of dietary compounds and may impact drug responses. Although GBA3 deficiency is not associated with a defined Mendelian disorder, variation in GBA3 may affect nutrition, pharmacology, and detoxification capacity. Because beta-glucosidases have roles in metabolic disease and cancer, GBA3 has been explored as a potential biomarker. NSJ Bioreagents provides GBA3 antibody to support research in nutrition, toxicology, and carbohydrate metabolism.
Experimentally, GBA3 antibody is applied in western blotting to detect the ~54 kDa protein, in immunohistochemistry to study expression in liver and intestine, and in enzymatic assays to confirm substrate specificity. Co-immunoprecipitation with GBA3 antibody helps identify partners in carbohydrate and xenobiotic metabolism pathways.
Optimal dilution of the GBA3 antibody should be determined by the researcher.
E.coli-derived human GBA3 recombinant protein (Position: Q17-L469) was used as the immunogen for the GBA3 antibody.
After reconstitution, the GBA3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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