- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
GATA4 Antibody / Cardiac Transcription Factor Antibody (R32844)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
R32844 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 449 |
|
| Species Reactivity | Human, Rat |
| Format | Antigen affinity purified |
| Host | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Antigen affinity |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose |
| UniProt | P43694 |
| Applications | Western Blot : 0.5-1ug/ml |
| Limitations | This GATA4 Antibody / Cardiac Transcription Factor Antibody is available for research use only. |
|
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GATA4 Antibody / Cardiac Transcription Factor Antibody recognizes GATA binding protein 4 (GATA4), a zinc finger transcription factor that plays a central role in embryonic development and tissue-specific gene regulation. GATA4 is best known as a master regulator of cardiac development, where it controls the expression of genes required for cardiomyocyte differentiation, cardiac morphogenesis and normal heart function. Through interactions with other cardiac transcription factors, GATA4 coordinates developmental programs essential for cardiovascular formation and adaptation. NSJ Bioreagents offers high-quality GATA4 Antibody reagents for investigating cardiac biology and transcriptional regulation.
GATA4 regulates numerous genes involved in myocardial growth, cell survival and cardiac remodeling throughout development and adulthood. It cooperates with transcription factors including NKX2-5, TBX5 and MEF2 family members to activate cardiac-specific gene expression and promote differentiation of cardiac progenitor cells. In addition to its developmental functions, GATA4 participates in the molecular response to cardiac stress, contributing to adaptive hypertrophy, myocardial repair and protection against apoptosis. As a result, GATA4 Antibody is widely used to investigate transcriptional networks controlling heart development and cardiovascular disease.
Beyond the cardiovascular system, GATA4 contributes to the development and function of several endoderm-derived organs, including the liver, pancreas, stomach and intestine, while also playing important roles in gonadal development and reproductive biology. Altered GATA4 expression has been associated with congenital heart defects, cancer progression and developmental disorders, making it an important target in both basic and translational research. Continued investigation of GATA4 has expanded understanding of how lineage-specific transcription factors regulate organogenesis, cellular differentiation and tissue homeostasis across multiple biological systems.
An GATA4 Antibody is a valuable reagent for investigating cardiac development, transcriptional regulation and organogenesis. A Cardiac Transcription Factor Antibody supports research involving heart development, congenital cardiovascular disorders, stem cell differentiation and developmental gene regulatory networks.
Researchers studying heart development, embryogenesis and lineage-specific gene regulation may also be interested in our Transcription Factor Antibodies page, featuring antibodies against key regulators of cellular differentiation and organ development.
Optimal dilution of the GATA4 Antibody / Cardiac Transcription Factor Antibody should be determined by the researcher.
Amino acids 419-442 (QTSSKQDSWNSLVLADSHGDIITA) were used as the immunogen for the GATA4 antibody.
After reconstitution, the GATA4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
GATA4 antibody, Cardiac Transcription Factor antibody, GATA Binding Protein 4 antibody, Transcription Factor GATA-4 antibody
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