- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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GATA2 Antibody / GATA Binding Protein 2 Antibody recognizes GATA2, a zinc finger transcription factor that plays a central role in hematopoiesis, stem and progenitor cell biology, and vascular development. GATA2 belongs to the GATA family of DNA-binding proteins, which recognize GATA sequence motifs within regulatory regions of target genes. The protein contains two characteristic zinc finger domains that contribute to DNA binding and interactions with transcriptional cofactors. Through regulation of lineage- and developmental-specific gene expression, GATA2 helps control cell proliferation, differentiation, survival, and maintenance of progenitor cell populations.
GATA2 is particularly important in the hematopoietic system. It is expressed in hematopoietic stem and progenitor cells and contributes to the maintenance and function of early blood-forming populations. GATA2 activity must be carefully regulated as cells progress through hematopoietic differentiation, and it interacts with broader transcriptional networks governing lineage commitment. GATA2 is also important in mast cell biology and contributes to the development and function of additional myeloid and lymphoid cell populations. A GATA2 Antibody can support studies of hematopoiesis, stem and progenitor cell regulation, blood cell differentiation, and transcriptional mechanisms controlling immune cell development.
Beyond hematopoiesis, GATA2 participates in endothelial and vascular biology and has important functions during embryonic development. Its transcriptional activity contributes to the regulation of genes involved in vascular integrity and developmental cell fate decisions. Altered GATA2 expression or function is also studied in human disease. Germline GATA2 variants are associated with disorders characterized by hematopoietic and immune abnormalities, while acquired alterations and dysregulated expression are investigated in myeloid malignancies and other cancers. A GATA Binding Protein 2 Antibody is therefore relevant to research involving developmental biology, hematologic disease, leukemia, transcriptional regulation, and cancer biology.
As a nuclear transcription factor positioned within several major developmental and hematopoietic regulatory networks, GATA2 is frequently investigated alongside other lineage-defining transcription factors and signaling proteins. Analysis of GATA2 expression can provide insight into cell identity, differentiation state, and changes in transcriptional programs associated with normal development or disease. NSJ Bioreagents offers antibodies for studying transcription factors and related regulatory pathways. A GATA2 Antibody is useful for investigating GATA Binding Protein 2 expression in hematopoiesis, stem cell biology, immune cell development, vascular biology, transcriptional regulation, and cancer research.
Explore our Transcription Factor Antibodies page to find additional antibodies for studying gene expression, hematopoietic differentiation, developmental regulation, and transcriptional control.
Optimal dilution of the GATA2 Antibody / GATA Binding Protein 2 Antibody should be determined by the researcher.
Recombinant human protein (amino acids D23-S288) was used as the immunogen for the GATA2 antibody.
After reconstitution, the GATA2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
GATA2 antibody, GATA Binding Protein 2 antibody, GATA-2 antibody, GATA Binding Factor 2 antibody, NFE1B antibody
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