GATA1 Antibody [clone ABCB-7] (RQ5460)

GATA1 Antibody Mouse Spleen IHC. Immunohistochemical staining of FFPE mouse spleen with GATA1 antibody demonstrated strong nuclear staining in erythroid precursor cells, consistent with the localization of GATA1 as a lineage-defining transcription factor. GATA1 is a zinc finger transcription factor that regulates genes required for erythropoiesis, hemoglobin synthesis, and terminal maturation of red blood cells while also contributing to megakaryocyte differentiation. The predominantly nuclear staining pattern reflects its role as a transcriptional regulator controlling hematopoietic gene expression. These results support the utility of GATA1 Antibody for studies of hematopoiesis, erythropoiesis, hematologic malignancies, and developmental hematology.

GATA1 Antibody Human Hematopoietic Cell WB. Western blot analysis of GATA1 expression was performed using anti-GATA1 antibody. Lane 1: human K562 cell lysate. Lane 2: human HEL cell lysate. Lane 3: human CCRF-CEM cell lysate. Lane 4: human Raji cell lysate. GATA1 is a zinc finger transcription factor that serves as a master regulator of erythropoiesis by controlling genes required for erythroid lineage commitment, hemoglobin synthesis, and red blood cell maturation. A specific immunoreactive band is detected at approximately 43 kDa, consistent with the expected molecular weight of GATA1. Strong expression is observed in the erythroid-derived K562 and HEL cell lines, supporting the established role of GATA1 in hematopoietic differentiation. These results demonstrate the utility of GATA1 Antibody for studies of hematopoiesis, erythropoiesis, developmental biology, and hematopoietic transcriptional regulation.