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- Tel: 858.663.9055
- Email: info@nsjbio.com
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GATA-3 (GATA binding protein 3) is a member of the GATA family of transcription factors. This 50kDa nuclear protein regulates the development and subsequent maintenance of a variety of human tissues, including hematopoietic cells, skin, kidney, mammary gland, and the central nervous system. Among several other roles, GATA-3 involved in luminal cell differentiation in the mammary gland and appears to control a set of genes involved in the differentiation and proliferation of breast cancer. The expression of GATA-3 is associated with the expression of estrogen receptor-alpha (ER) in breast cancer. GATA-3 has been shown to be a novel marker for bladder cancer. The study demonstrated that GATA-3 stained 67% of urothelial Carcinomas, but none of prostate or renal carcinomas.
Optimal dilution of the GATA-3 antibody should be determined by the researcher.
Recombinant full-length human GATA-3 protein was used as the immunogen for the GATA-3 antibody.
Aliquot the GATA-3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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