- Tel: 858.663.9055
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
GAT-1 Antibody / GABA Transporter 1 / SLC6A1 (C-Terminal Region) (R30811)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
 |
R30811 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 429 |
| Availability | 1-3 business days |
| Species Reactivity | Human, Mouse, Rat |
| Format | Antigen affinity purified |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Antigen affinity |
| Buffer | Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal |
| UniProt | P30531 |
| Localization | Membrane |
| Applications | Western blot : 0.5-1ug/ml IHC (FFPE) : 0.5-1ug/ml |
| Limitations | This GAT-1 antibody is available for research use only. |
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SLC6A1 (Solute Carrier family 6 (Neurotransmitter transporter, Gaba), Member 1), also called GABATR, GABATHG and GAT-1, encodes a gamma-aminobutyric acid (GABA) transporter, which removes GABA from the synaptic cleft. Zomot et al.(2007) showed that introduction of a negatively charged amino acid at or near one of the two putative sodium binding sites of GAT-1 from rat brain renders both net flux and exchange of GABA largely chloride independent. By in vitro functional expression studies, the GAT-1 insertion promoter (two copies of the sequence) had significantly greater promoter activity than the noninsertion (one copy of the sequence) promoter, which in turn had greater activity than a promoterless control. Studies of postmortem hippocampus from 69 African American individuals showed that overall expression decreased with age.
The stated application concentrations are suggested starting amounts. Titration of the GAT-1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
An amino acid sequence from the C-terminus of human GABA Transporter 1 (WFYGVNRFYDNIQEM) was used as the immunogen for this GAT-1 antibody (100% homologous in human, mouse and rat).
After reconstitution, the GAT-1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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