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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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Gastrotropin Antibody / Intestinal Lipid Binding Protein Antibody recognizes FABP6, a member of the fatty acid binding protein family that functions as an intracellular transporter of bile acids and other hydrophobic molecules. Originally identified as Gastrotropin, this protein is highly expressed in the distal small intestine where it facilitates the intracellular trafficking of bile acids during enterohepatic circulation. Also known as Ileal Lipid Binding Protein, FABP6 binds bile salts with high affinity and contributes to the efficient absorption and recycling of nutrients. Through its role in bile acid transport, Gastrotropin helps maintain lipid homeostasis and normal gastrointestinal physiology.
Gastrotropin functions in concert with membrane transporters and metabolic regulators that govern bile acid synthesis and signaling. Following intestinal uptake, bile acids are transported through enterocytes and returned to the liver, where they participate in cholesterol metabolism and lipid digestion. In addition to their digestive functions, bile acids act as signaling molecules that regulate glucose homeostasis, inflammation, and energy metabolism. By controlling intracellular bile acid trafficking, Intestinal Lipid Binding Protein contributes to communication between the intestine and liver and influences multiple metabolic pathways.
Altered expression of FABP6 has been associated with inflammatory bowel disease, cholestatic liver disorders, metabolic syndrome, and gastrointestinal malignancies. Increased expression of Gastrotropin has been reported in colorectal and gastric cancers, where dysregulated bile acid signaling may contribute to tumor progression and metabolic adaptation. Disturbances in bile acid homeostasis have also been linked to chronic inflammation and abnormalities in lipid metabolism. Consequently, FABP6 has emerged as a useful biomarker for studies of intestinal differentiation and gastrointestinal disease.
Beyond the intestine, bile acid signaling pathways influence mitochondrial function, oxidative stress responses, and inflammatory cascades. Because bile acids function as endocrine regulators affecting multiple organs, proteins involved in their intracellular transport have become increasingly important in studies of metabolism and disease mechanisms. The ability of Gastrotropin to coordinate bile acid handling highlights its importance in maintaining metabolic homeostasis.
Gastrotropin Antibody / Intestinal Lipid Binding Protein Antibody is useful for investigations of bile acid transport, nutrient absorption, intestinal physiology, metabolic disease, and cancer biology. Published studies have utilized FABP6 antibodies to examine gastrointestinal homeostasis and metabolic regulation. The ability to detect endogenous Gastrotropin makes this antibody a valuable tool for studies of enterohepatic circulation, bile acid signaling, and disorders affecting intestinal function.
Explore our FABP6 Antibody page for additional antibodies against this Bile Acid Binding Protein, including reagents for studies of bile acid transport, enterohepatic circulation, and metabolic homeostasis.
Optimal dilution of the Gastrotropin Antibody / Intestinal Lipid Binding Protein Antibody should be determined by the researcher.
Recombinant human protein (amino acids M1-A128) was used as the immunogen for the Gastrotropin antibody.
After reconstitution, the Gastrotropin antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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