- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
FUBP2 Antibody / Far upstream element-binding protein 2 / KHSRP (RQ7979)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
RQ7979 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 449 |
| Availability | 1-3 business days |
| Species Reactivity | Human, Mouse, Rat |
| Format | Antigen affinity purified |
| Host | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Antigen affinity purified |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose |
| UniProt | Q92945 |
| Localization | Cytoplasmic, nuclear |
| Applications | Western Blot : 0.5-1ug/ml Immunohistochemistry (FFPE) : 2-5ug/ml Immunofluorescence : 5ug/ml Flow Cytometry : 1-3ug/million cells Immunoprecipitation : 2ug per 500ug of lysate Direct ELISA : 0.1-0.5ug/ml |
| Limitations | This FUBP2 antibody is available for research use only. |
|
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FUBP2 Antibody targets Far upstream element-binding protein 2, also called KH type-splicing regulatory protein, a single-stranded nucleic acid-binding protein encoded by the KHSRP gene that plays an important role in post-transcriptional gene regulation. Far upstream element-binding protein 2 belongs to the FUBP family of RNA-binding proteins, which are characterized by their ability to interact with single-stranded DNA and RNA sequences and influence gene expression at multiple regulatory levels. FUBP2 is closely related to other family members involved in transcriptional and RNA processing pathways.
Functionally, Far upstream element-binding protein 2 is primarily recognized for its role in RNA binding and regulation of mRNA stability, transport, and translation. By interacting with specific RNA sequences, FUBP2 can influence the fate of target transcripts and contribute to fine-tuning of gene expression programs. A FUBP2 Antibody enables investigation of RNA-protein interactions and post-transcriptional regulatory mechanisms that shape cellular protein output in both normal and disease-associated contexts.
FUBP2 expression is observed across a broad range of tissues and cell types, reflecting its involvement in fundamental regulatory processes. At the subcellular level, Far upstream element-binding protein 2 is predominantly localized to the nucleus, where it participates in RNA processing and regulatory complexes, but it may also be detected in the cytoplasm depending on cellular state and regulatory activity. Shifts in FUBP2 localization can reflect changes in RNA metabolism or cellular responses to stress and signaling cues.
At the molecular level, Far upstream element-binding protein 2 contains multiple KH-type RNA-binding domains that mediate sequence-specific interactions with single-stranded nucleic acids. These domains enable FUBP2 to recognize and bind regulatory elements within RNA targets, supporting its role as a versatile modulator of gene expression. The modular domain structure allows FUBP2 to interact with a range of RNA species and regulatory partners, integrating RNA binding with broader gene regulatory networks.
From a biological and disease relevance perspective, FUBP2 has been investigated in studies of cell proliferation, differentiation, and stress responses, where post-transcriptional regulation is essential for adaptive gene expression. Altered expression or activity of RNA-binding proteins such as FUBP2 has been associated with dysregulated gene expression programs in cancer and other diseases. As a result, FUBP2 is of interest as a component of RNA regulatory pathways that contribute to cellular homeostasis and disease-associated transcriptional remodeling.
FUBP2 Antibody reagents are valuable tools for studying RNA-binding protein function, post-transcriptional regulation, and gene expression control. These antibodies support research into RNA metabolism, nuclear regulatory complexes, and disease-associated alterations in RNA-protein interactions. NSJ Bioreagents provides FUBP2 Antibody products intended for research use.
Optimal dilution of the FUBP2 antibody should be determined by the researcher.
E. coli-derived recombinant human protein (amino acids D116-R478) was used as the immunogen for the FUBP2 antibody.
After reconstitution, the FUBP2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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