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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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Ferritin Heavy Chain 1 (FTH1), commonly known as Ferritin Heavy Chain, is an intracellular iron storage protein involved in iron sequestration, ferroxidase activity, oxidative stress regulation, and maintenance of cellular iron homeostasis. FTH1 Antibody / Ferritin Heavy Chain 1 Antibody recognizes a conserved ferritin complex subunit responsible for detoxification and intracellular storage of excess iron within ferritin nanocage structures.
FTH1 antibody, also referred to as Ferritin Heavy Chain antibody and Ferritin H antibody in the literature, is useful for investigation of iron metabolism pathways, oxidative stress adaptation, ferroptosis-associated signaling, and metabolic regulation. Monoclonal clone FTH/2081 supports studies examining intracellular ferritin expression across multiple tissues, epithelial-derived tumors, and metabolically active cellular systems.
Ferritin complexes are assembled from heavy and light chain ferritin subunits that collectively regulate intracellular iron buffering and storage capacity. The heavy chain component encoded by FTH1 provides ferroxidase activity required for conversion of reactive ferrous iron into ferric iron prior to sequestration within ferritin complexes, thereby limiting oxidative injury associated with excess free iron accumulation.
FTH1 expression is broadly distributed across brain, kidney, lung, pancreas, and epithelial cellular systems where iron metabolism and oxidative stress adaptation are critical for normal cellular physiology. Because iron homeostasis influences mitochondrial metabolism, DNA synthesis, cellular proliferation, and reactive oxygen species-associated signaling, Ferritin Heavy Chain 1 contributes to multiple metabolic and stress-associated pathways.
In cancer-associated research, elevated FTH1 expression has been linked to tumor-associated metabolic adaptation, inflammatory signaling, ferroptosis resistance, and oxidative stress protection mechanisms. Ferritin-associated pathways have therefore become increasingly important in studies examining tumor metabolism, iron dependency states, and cellular stress response signaling.
Western blot analysis with FTH1 antibodies commonly demonstrates monomeric Ferritin Heavy Chain near approximately 20-24 kDa across multiple tissue and cell line lysates, while immunohistochemistry staining frequently reveals granular cytoplasmic staining patterns consistent with intracellular ferritin localization in metabolically active tissues and epithelial-derived tumors.
The broad cross-species expression profile observed with clone FTH/2081 supports the conserved role of FTH1 in intracellular iron regulation and oxidative stress-associated metabolic homeostasis. The biologic importance of ferritin-mediated iron sequestration further supports the value of FTH1 antibodies in metabolism and ferroptosis-related research applications.
Together, the available western blot and immunohistochemistry data support the use of FTH1 antibody clone FTH/2081 for investigating intracellular iron storage pathways, ferritin-associated oxidative stress regulation, and ferroptosis-linked metabolic signaling.
For additional ferritin and iron metabolism research antibodies featuring broad multi-species western blot validation, explore the broader Ferritin Heavy Chain Antibody page featuring recombinant clone FTH/8700R.
Optimal dilution of the FTH1 Antibody / Ferritin Heavy Chain 1 Antibody should be determined by the researcher.
A human recombinant partial protein (amino acids 58-180) were used as the immunogen for the FTH1 antibody.
Store the FTH1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
FTH1 antibody, Ferritin Heavy Chain antibody, Ferritin H antibody, ferritin heavy polypeptide 1 antibody, iron metabolism protein antibody
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