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Home >> Antibodies >> FSCN1 Antibody / Fascin 1

FSCN1 Antibody / Fascin 1 [clone FSCN1/7209] (V4051)

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  Catalog No Formulation Size Price (USD)  
Image V4051-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 519
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V4051-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 229
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V4051SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
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IHC staining of FFPE human Hodgkin's lymphoma with FSCN1 antibody (clone FSCN1/7209). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
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IHC staining of FFPE human Hodgkin's lymphoma with FSCN1 antibody (clone FSCN1/7209). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
IHC staining of FFPE human kidney tissue with FSCN1 antibody (clone FSCN1/7209). Negative control inset: PBS used instead of primary antibody to control for secondary Ab binding. HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG2a, kappa
Clone Name FSCN1/7209
Purity Protein A/G affinity
UniProt Q16658
Localization Cytoplasm
Applications Immunohistochemistry (FFPE) : 1-3ug/ml
Limitations This FSCN1 antibody is available for research use only.
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Description

Recognizes a protein of 55kDa, which is identified as fascin-1. Its actin binding ability is regulated by phosphorylation. Antibody to fascin-1 is a very sensitive marker for Reed-Sternberg cells and variants in nodular sclerosis, mixed cellularity, and lymphocyte depletion Hodgkin s disease. It is uniformly negative in lymphoid cells, plasma cells, and myeloid cells. Fascin-1 is also expressed in dendritic cells. This marker may be helpful to distinguish between Hodgkin lymphoma and non-Hodgkin lymphoma in difficult cases. Also, the lack of expression of fascin-1 in the neoplastic follicles in follicular lymphoma may be helpful in distinguishing these lymphomas from reactive follicular hyperplasia in which the number of follicular dendritic cells is normal or increased. Antibody to fascin-1 has been suggested as a prognostic marker in neuroendocrine neoplasms of the lung as well as in ovarian cancer. Fascin-1 expression may be induced by Epstein-Barr virus (EBV) infection of B cells with the possibility that viral induction of fascin in lymphoid or other cell types must also be considered in EBV-positive cases.

Application Notes

Optimal dilution of the FSCN1 antibody should be determined by the researcher.

Immunogen

A portion of amino acids 350-400 from the human FSCN1 protein was used as the immunogen for the FSCN1 antibody.

Storage

Aliquot the FSCN1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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