- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Frizzled 8 Antibody / Wnt Signaling Receptor Antibody (R36118)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
R36118-100UG | 0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide | 100 ug | 475 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Predicted Reactivity | Cow, Dog, Mouse, Rat |
| Format | Antigen affinity purified |
| Host | Goat |
| Clonality | Polyclonal (goat origin) |
| Isotype | Goat Ig |
| Purity | Antigen affinity |
| Gene ID | 8325 |
| Applications | Western Blot : 1-3ug/ml Immunohistochemistry (FFPE) : 3-5ug/ml ELISA (peptide) LOD : 1:32000 |
| Limitations | This Frizzled 8 Antibody / Wnt Signaling Receptor Antibody is available for research use only. |
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Frizzled 8 Antibody / Wnt Signaling Receptor Antibody recognizes Frizzled 8 (FZD8), a seven-transmembrane receptor that functions as a key mediator of canonical and non-canonical Wnt signaling pathways. As a member of the Frizzled receptor family, FZD8 binds extracellular Wnt ligands and transduces signals that regulate cell proliferation, differentiation, polarity, migration, and tissue patterning. Through activation of beta-catenin-dependent and beta-catenin-independent pathways, FZD8 plays an essential role during embryonic development while continuing to regulate tissue homeostasis and regeneration in adult organisms. Frizzled 8 Antibody / Wnt Signaling Receptor Antibody is widely used to investigate developmental signaling, stem cell biology, and receptor-mediated signal transduction.
FZD8 is expressed in multiple tissues where it participates in neural development, skeletal formation, cardiovascular development, organogenesis, and maintenance of stem cell populations. Ligand binding promotes assembly of receptor complexes that activate intracellular signaling cascades controlling gene expression, cytoskeletal organization, and cell fate decisions. Because Wnt signaling is highly conserved across vertebrates, FZD8 has become an important target for studies examining embryonic patterning, tissue repair, regeneration, and developmental disorders.
Dysregulation of FZD8-mediated signaling has been implicated in numerous diseases, including colorectal cancer, breast cancer, hepatocellular carcinoma, gastric cancer, and other malignancies in which aberrant Wnt pathway activation promotes uncontrolled proliferation, epithelial-to-mesenchymal transition, invasion, and therapeutic resistance. FZD8 has also been investigated for its roles in fibrosis, bone metabolism, and regenerative medicine, making it an important biomarker and potential therapeutic target for modulation of Wnt signaling.
NSJ Bioreagents' Frizzled 8 Antibody / Wnt Signaling Receptor Antibody supports investigations into Wnt signaling, embryonic development, tissue regeneration, stem cell biology, cancer progression, and receptor-mediated signaling pathways. Detection of endogenous FZD8 expression enables researchers to examine one of the principal receptors controlling vertebrate developmental and homeostatic signaling networks.
Explore additional antibodies involved in stem cell maintenance, Wnt signaling, and cellular differentiation on our Stem Cell Antibodies page.
Optimal dilution of the Frizzled 8 Antibody / Wnt Signaling Receptor Antibody should be determined by the researcher.
Amino acids SYPKQMPLSQV were used as the immunogen for this Frizzled 8 antibody.
Aliquot and store the Frizzled 8 antibody at -20oC.
Frizzled 8 antibody, FZD8 antibody, Frizzled-8 receptor antibody, Fz8 antibody, Wnt Receptor antibody, Frizzled Family Receptor antibody
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