FRA2 Antibody FOSL2 AP-1 Marker Clone PCRP-FOSL2-1B1

	Catalog No	Formulation	Size	Price (USD)
	V8958-100UG	0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide	100 ug	559
Formulation
	V8958-20UG	0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide	20 ug	259
Formulation
	V8958SAF-100UG	1 mg/ml in 1X PBS; BSA free, sodium azide free	100 ug	559
Formulation

FRA2 Antibody FACS. Flow cytometry analysis of PFA-fixed human HeLa cells stained with FRA2 Antibody / FOSL2 AP-1 Transcription Factor Antibody clone PCRP-FOSL2-1B1 (blue) demonstrates a distinct positive fluorescence shift relative to the isotype control (red), consistent with intracellular detection of Fos-related antigen 2 / FOSL2, a nuclear AP-1 family transcription factor involved in proliferation signaling, stress-response pathways, and transcriptional regulation.

FRA2 Antibody IF. Immunofluorescent staining of PFA-fixed human HeLa cells using FRA2 Antibody / FOSL2 AP-1 Transcription Factor Antibody clone PCRP-FOSL2-1B1 (green) demonstrates predominantly nuclear staining consistent with the expected localization of Fos-related antigen 2 / FOSL2 as an AP-1 family transcription factor. Phalloidin counterstaining (red) highlights the actin cytoskeleton and cellular morphology.

SDS-PAGE analysis of purified, BSA-free FRA2 antibody (PCRP-FOSL2-1B1) as confirmation of integrity and purity.

FRA2 Antibody Protein Microarray Specificity Analysis. Analysis of HuProt(TM) microarray containing more than 19,000 full-length human proteins using FRA2 Antibody / FOSL2 AP-1 Transcription Factor Antibody (clone PCRP-FOSL2-1B1). HuProt testing identified FOSL2 as the top-ranked target for this clone, with additional lower-ranked signals detected for other proteins. The Z-score represents signal strength generated by antibody binding relative to the mean array signal, while the S-score reflects the difference in signal intensity between successive ranked targets. These findings support target reactivity for FOSL2 while complementary IF and FACS data provide additional application-based validation context for clone PCRP-FOSL2-1B1.

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FRA2 Antibody FACS. Flow cytometry analysis of PFA-fixed human HeLa cells stained with FRA2 Antibody / FOSL2 AP-1 Transcription Factor Antibody clone PCRP-FOSL2-1B1 (blue) demonstrates a distinct positive fluorescence shift relative to the isotype control (red), consistent with intracellular detection of Fos-related antigen 2 / FOSL2, a nuclear AP-1 family transcription factor involved in proliferation signaling, stress-response pathways, and transcriptional regulation.

FRA2 Antibody IF. Immunofluorescent staining of PFA-fixed human HeLa cells using FRA2 Antibody / FOSL2 AP-1 Transcription Factor Antibody clone PCRP-FOSL2-1B1 (green) demonstrates predominantly nuclear staining consistent with the expected localization of Fos-related antigen 2 / FOSL2 as an AP-1 family transcription factor. Phalloidin counterstaining (red) highlights the actin cytoskeleton and cellular morphology.

SDS-PAGE analysis of purified, BSA-free FRA2 antibody (PCRP-FOSL2-1B1) as confirmation of integrity and purity.

FRA2 Antibody Protein Microarray Specificity Analysis. Analysis of HuProt(TM) microarray containing more than 19,000 full-length human proteins using FRA2 Antibody / FOSL2 AP-1 Transcription Factor Antibody (clone PCRP-FOSL2-1B1). HuProt testing identified FOSL2 as the top-ranked target for this clone, with additional lower-ranked signals detected for other proteins. The Z-score represents signal strength generated by antibody binding relative to the mean array signal, while the S-score reflects the difference in signal intensity between successive ranked targets. These findings support target reactivity for FOSL2 while complementary IF and FACS data provide additional application-based validation context for clone PCRP-FOSL2-1B1.

Availability	1-3 business days
Species Reactivity	Human
Format	Purified
Host	Mouse
Clonality	Monoclonal (mouse origin)
Isotype	Mouse IgG1
Clone Name	PCRP-FOSL2-1B1
Purity	Protein A/G affinity
UniProt	P15408
Localization	Nucleus
Applications	Flow Cytometry : 1-2ug/million cells Immunofluorescence : 1-2ug/ml
Limitations	This FRA2 Antibody / FOSL2 AP-1 Transcription Factor Antibody is available for research use only.
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Description

Fos-related antigen 2 (FOSL2) is a member of the Fos family of AP-1 transcription factors that regulate gene expression involved in cellular proliferation, differentiation, inflammatory signaling, tissue remodeling, and oncogenic transformation. FRA2 Antibody / FOSL2 AP-1 Transcription Factor Antibody recognizes a nuclear regulatory protein that heterodimerizes with JUN family members to form functional AP-1 transcriptional complexes capable of modulating stimulus-responsive gene expression programs.

FRA2 antibody, also referred to as FOSL2 antibody and Fos-related antigen 2 antibody in the literature, is useful for studying AP-1 pathway activation in cancer biology, fibrosis research, immune signaling, and developmental regulation. Clone PCRP-FOSL2-1B1 antibody provides a useful tool for examining FOSL2 expression patterns in cultured cells and tissue samples, particularly in studies focused on transcriptional control mechanisms and stress-responsive signaling pathways.

FOSL2 is primarily localized to the nucleus where it functions as a DNA-binding transcriptional regulator following dimerization with JUN proteins such as JUN, JUNB, and JUND. The protein participates in MAPK-responsive signaling cascades and is induced downstream of growth factor stimulation, inflammatory cytokines, oxidative stress, and oncogenic signaling networks. AP-1 complexes containing FOSL2 regulate genes associated with extracellular matrix remodeling, epithelial-mesenchymal transition, angiogenesis, immune modulation, and cellular migration. Increased FOSL2 expression has been associated with fibrotic disorders, breast cancer progression, lung cancer biology, and invasive tumor phenotypes.

FOSL2 belongs to the basic leucine zipper (bZIP) transcription factor family and contains a characteristic leucine zipper dimerization domain together with a DNA-binding basic region required for AP-1 complex formation and promoter recognition. Functional studies have demonstrated that FOSL2 contributes to transcriptional plasticity during cellular adaptation responses and can cooperate with additional signaling pathways including TGF-beta, MAPK, and inflammatory transcriptional programs. In mesenchymal and stromal cell populations, FOSL2 has been implicated in collagen production and extracellular matrix regulation, supporting interest in this target in fibrosis and wound healing research.

HuProt microarray testing of clone PCRP-FOSL2-1B1 identified FOSL2 as the top-ranked target among more than 19,000 full-length human proteins analyzed. Additional lower-ranked signals were also observed, supporting target reactivity while complementary immunofluorescence and flow cytometry data provide additional application-based validation context for this clone. The observed reactivity profile supports the use of this FRA2 antibody for investigating AP-1 transcription factor expression patterns and transcriptional regulation mechanisms in cell biology and cancer research applications.

Explore additional nuclear regulatory targets on the Transcription Factor Antibodies page, including AP-1 pathway proteins, JUN/FOS family members, and other transcriptional regulators.

Application Notes

Optimal dilution of the FRA2 Antibody / FOSL2 AP-1 Transcription Factor Antibody should be determined by the researcher.

Immunogen

Recombinant full-length human FOSL2 protein was used as the immunogen for the FRA2 antibody.

Storage

Aliquot the FRA2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Alternate Names

FOSL2 antibody, Fra-2 antibody, AP-1 transcription factor antibody, Fos-related antigen 2 antibody, FRA2 IF antibody

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