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Home >> Antibodies >> FOXP1 Antibody / Forkhead Box Protein P1 Antibody

FOXP1 Antibody / Forkhead Box Protein P1 Antibody [clone FOXP1/9381R] (V5620)

  Catalog No Formulation Size Price (USD)  
Image V5620-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 559
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V5620-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 259
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V5620SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 559
Microvalidated Recrabbitmono
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FOXP1 Antibody Ramos WB. Western blot analysis of Ramos cell lysate using Forkhead Box Protein P1 Antibody clone FOXP1/9381R. A distinct band is detected at approximately 75-80 kDa, consistent with the expected molecular weight of Forkhead box protein P1 / FOXP1, a transcription factor involved in B-cell differentiation, lymphoid development, and transcriptional regulation. The observed signal is consistent with the established expression of FOXP1 in B-cell lineage-derived Ramos cells.
SDS-PAGE analysis of purified, BSA-free FOXP1 antibody (clone FOXP1/9381R) as confirmation of integrity and purity.
FOXP1 Antibody Human Prostate Carcinoma IHC. Immunohistochemical staining of FFPE human prostate carcinoma tissue using FOXP1 Antibody / Forkhead Box Protein P1 Antibody. Following heat-induced epitope retrieval in pH 9 Tris-EDTA buffer, strong nuclear staining is observed in the malignant epithelial cells, consistent with the expected subcellular localization of FOXP1. The inset shows the negative control, in which PBS was substituted for the primary antibody, demonstrating the specificity of the immunostaining. This FOXP1 Antibody, a Forkhead Box Protein P1 Antibody, is well suited for immunohistochemical studies of transcriptional regulation, prostate cancer biology and FOXP1 expression in tumor tissues.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Host Rabbit
Clonality Recombinant Rabbit Monoclonal
Isotype Rabbit IgG, kappa
Clone Name FOXP1/9381R
Purity Protein A/G affinity
UniProt Q9H334
Localization Nucleus
Applications Immunohistochemistry (FFPE) : 1-2ug/ml
Western Blot : 2-4ug/ml
Limitations This FOXP1 Antibody / Forkhead Box Protein P1 Antibody is available for research use only.
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Description

FOXP1 Antibody / Forkhead Box Protein P1 Antibody recognizes Forkhead Box Protein P1 (FOXP1), a DNA-binding transcription factor belonging to the forkhead box P subfamily. FOXP1 regulates gene expression programs that control cellular differentiation, proliferation and tissue development through sequence-specific DNA binding and interactions with transcriptional co-regulators. It is broadly expressed in lymphoid tissues, heart, lung, brain and epithelial organs, reflecting its essential roles in normal physiology. NSJ Bioreagents offers FOXP1 antibodies to support investigations of developmental biology, immunology, neuroscience and oncology.

Forkhead Box Protein P1 is a key regulator of immune cell development, particularly within B lymphocytes and T lymphocytes, where it influences lineage specification, maturation and functional responses. During embryonic development, FOXP1 contributes to formation of the cardiovascular system, lungs and central nervous system while helping coordinate cellular differentiation and organogenesis. In the brain, FOXP1 is highly expressed in selected neuronal populations and participates in neural circuit formation, synaptic maturation and higher cognitive function. A FOXP1 Antibody is therefore valuable for studying transcriptional networks that govern normal development and tissue-specific gene expression.

Altered expression or mutation of FOXP1 has been implicated in diffuse large B-cell lymphoma, mucosa-associated lymphoid tissue lymphoma, chronic lymphocytic leukemia and numerous solid tumors. Depending on cellular context, Forkhead Box Protein P1 may function as either a tumor suppressor or an oncogenic transcriptional regulator. Germline variants in FOXP1 are also associated with neurodevelopmental disorders characterized by intellectual disability, language impairment and autism spectrum features. Researchers frequently use FOXP1 Antibody to examine nuclear protein expression, investigate transcriptional regulation and characterize disease-associated changes in FOXP1 signaling.

An FOXP1 Antibody is a valuable reagent for detecting Forkhead Box Protein P1 by Western blotting, immunohistochemistry, immunofluorescence, flow cytometry and related immunoassays. A Forkhead Box Protein P1 Antibody supports studies of transcriptional regulation, immune cell biology, neuronal development, organogenesis and cancer research.

For an overview of FOXP1 biology and its roles in transcriptional regulation, development and cancer, visit our FOXP1 Antibody / Forkhead Transcription Factor Antibody page.

Application Notes

Optimal dilution of the FOXP1 Antibody / Forkhead Box Protein P1 Antibody should be determined by the researcher.

Immunogen

A recombinant fragment (within amino acids 350-450) of human FOXP1 protein was used as the immunogen for the FOXP1 antibody.

Storage

Aliquot the FOXP1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Alternate Names

FOXP1 antibody, Forkhead Box Protein P1 antibody, HSPC215 antibody, QRF1 antibody

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